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High virulence sub-populations in Pseudomonas aeruginosa long-term cystic fibrosis airway infections

Overview of attention for article published in BMC Microbiology, February 2017
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (88th percentile)
  • High Attention Score compared to outputs of the same age and source (90th percentile)

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1 blog
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36 Dimensions

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92 Mendeley
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Title
High virulence sub-populations in Pseudomonas aeruginosa long-term cystic fibrosis airway infections
Published in
BMC Microbiology, February 2017
DOI 10.1186/s12866-017-0941-6
Pubmed ID
Authors

Siobhán O’Brien, David Williams, Joanne L. Fothergill, Steve Paterson, Craig Winstanley, Michael A. Brockhurst

Abstract

Pseudomonas aeruginosa typically displays loss of virulence-associated secretions over the course of chronic cystic fibrosis infections. This has led to the suggestion that virulence is a costly attribute in chronic infections. However, previous reports suggest that overproducing (OP) virulent pathotypes can coexist with non-producing mutants in the CF lung for many years. The consequences of such within-patient phenotypic diversity for the success of this pathogen are not fully understood. Here, we provide in-depth quantification of within-host variation in the production of three virulence associated secretions in the Liverpool cystic fibrosis epidemic strain of P. aeruginosa, and investgate the effect of this phenotypic variation on virulence in acute infections of an insect host model. Within-patient variation was present for all three secretions (pyoverdine, pyocyanin and LasA protease). In two out of three patients sampled, OP isolates coexisted with under-producing mutants. In the third patient, all 39 isolates were under-producers of all three secretions relative to the transmissible ancestor LESB58. Finally, this phenotypic variation translated into variation in virulence in an insect host model. Within population variation in the production of P. aeruginosa virulence-associated secretions can lead to high virulence sub-populations persisting in patients with chronic CF infections.

X Demographics

X Demographics

The data shown below were collected from the profiles of 12 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 92 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Canada 1 1%
Unknown 91 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 23 25%
Student > Bachelor 16 17%
Researcher 10 11%
Student > Master 9 10%
Student > Doctoral Student 7 8%
Other 12 13%
Unknown 15 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 20 22%
Immunology and Microbiology 19 21%
Biochemistry, Genetics and Molecular Biology 12 13%
Pharmacology, Toxicology and Pharmaceutical Science 7 8%
Chemistry 5 5%
Other 9 10%
Unknown 20 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 April 2017.
All research outputs
#2,544,519
of 25,074,338 outputs
Outputs from BMC Microbiology
#173
of 3,460 outputs
Outputs of similar age
#51,726
of 431,620 outputs
Outputs of similar age from BMC Microbiology
#5
of 44 outputs
Altmetric has tracked 25,074,338 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,460 research outputs from this source. They receive a mean Attention Score of 4.2. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 431,620 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 44 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.