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Epithelial stem cell culture: modeling human disease and applications for regenerative medicine

Overview of attention for article published in Inflammation and Regeneration, February 2017
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  • High Attention Score compared to outputs of the same age and source (83rd percentile)

Mentioned by

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4 X users

Citations

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6 Dimensions

Readers on

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48 Mendeley
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Title
Epithelial stem cell culture: modeling human disease and applications for regenerative medicine
Published in
Inflammation and Regeneration, February 2017
DOI 10.1186/s41232-017-0034-9
Pubmed ID
Authors

Yusuke Yamamoto, Takahiro Ochiya

Abstract

The inability to maintain the immaturity of stem cell populations in vitro restricts the long-term expansion of various types of human epithelial stem cells. However, recent technical advances in epithelial stem cell culture have led to the development of novel in vitro strategies for regenerating epithelial tissues and for closely mimicking human diseases such as cancer and inflammation. Specifically, improvements in culture conditions provided by small molecules in combination with three-dimensional (3D) culture approaches have facilitated the establishment of in vitro systems that recapitulate biological properties in epithelial organs, and these systems may be used to model disease. In this review article, we describe the biological significance of technical improvements in the development of these methods, focusing on human epithelial cells, including stratified and columnar epithelial cells. We also discuss the potential and future perspectives of this technology, which is only beginning to be explored.

X Demographics

X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 48 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Iran, Islamic Republic of 1 2%
Unknown 47 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 19%
Student > Bachelor 7 15%
Student > Ph. D. Student 5 10%
Student > Master 5 10%
Student > Doctoral Student 3 6%
Other 7 15%
Unknown 12 25%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 12 25%
Medicine and Dentistry 7 15%
Agricultural and Biological Sciences 6 13%
Immunology and Microbiology 3 6%
Engineering 2 4%
Other 4 8%
Unknown 14 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 July 2017.
All research outputs
#14,835,576
of 25,448,590 outputs
Outputs from Inflammation and Regeneration
#118
of 261 outputs
Outputs of similar age
#218,177
of 425,188 outputs
Outputs of similar age from Inflammation and Regeneration
#2
of 6 outputs
Altmetric has tracked 25,448,590 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 261 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.7. This one has gotten more attention than average, scoring higher than 55% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 425,188 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.