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Targeting inhibitor of apoptosis proteins in combination with ErbB antagonists in breast cancer

Overview of attention for article published in Breast Cancer Research, June 2009
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (83rd percentile)
  • Above-average Attention Score compared to outputs of the same age and source (64th percentile)

Mentioned by

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1 X user
patent
2 patents
googleplus
1 Google+ user

Citations

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70 Dimensions

Readers on

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62 Mendeley
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Title
Targeting inhibitor of apoptosis proteins in combination with ErbB antagonists in breast cancer
Published in
Breast Cancer Research, June 2009
DOI 10.1186/bcr2328
Pubmed ID
Authors

Fiona M Foster, Thomas W Owens, Jolanta Tanianis-Hughes, Robert B Clarke, Keith Brennan, Nigel J Bundred, Charles H Streuli

Abstract

Inhibitor of apoptosis (IAPs) proteins are a family of proteins that can block apoptosis in normal cells and have been suggested to cause resistance to apoptosis in cancer. Overexpression of oncogenic receptor tyrosine kinases is common in breast cancer; in particular 20% of all cases show elevated Her2. Despite clinical success with the use of targeted therapies, such as Trastuzumab, only up to 35% of Her2-positive patients initially respond. We reasoned that IAP-mediated apoptosis resistance might contribute to this insensitivity to receptor tyrosine kinase therapy, in particular ErbB antagonists. Here we examine the levels of IAPs in breast cancer and evaluate whether targeting IAPs can enhance apoptosis in response to growth factor receptor antagonists and TRAIL.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 62 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Iran, Islamic Republic of 1 2%
Spain 1 2%
United States 1 2%
Unknown 59 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 18 29%
Student > Ph. D. Student 10 16%
Student > Bachelor 6 10%
Other 5 8%
Student > Master 5 8%
Other 9 15%
Unknown 9 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 27 44%
Medicine and Dentistry 7 11%
Biochemistry, Genetics and Molecular Biology 7 11%
Chemistry 2 3%
Pharmacology, Toxicology and Pharmaceutical Science 1 2%
Other 6 10%
Unknown 12 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 July 2021.
All research outputs
#4,659,519
of 25,374,647 outputs
Outputs from Breast Cancer Research
#533
of 2,052 outputs
Outputs of similar age
#19,896
of 122,968 outputs
Outputs of similar age from Breast Cancer Research
#6
of 17 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done well and is in the 81st percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,052 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.2. This one has gotten more attention than average, scoring higher than 73% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 122,968 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 17 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.