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Resveratrol, a sirtuin 1 activator, increases IL-6 production by peripheral blood mononuclear cells of patients with knee osteoarthritis

Overview of attention for article published in Clinical Epigenetics, July 2013
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Title
Resveratrol, a sirtuin 1 activator, increases IL-6 production by peripheral blood mononuclear cells of patients with knee osteoarthritis
Published in
Clinical Epigenetics, July 2013
DOI 10.1186/1868-7083-5-10
Pubmed ID
Authors

Daniel Wendling, Wasim Abbas, Marie Godfrin-Valnet, Xavier Guillot, Kashif Aziz Khan, Jean-Pierre Cedoz, Lucile Baud, Clément Prati, Georges Herbein

Abstract

Sirtuin 1 (Sirt1) is a nuclear enzyme from the class III histone deacetylases that modulates gene expression and is involved in bone and cartilage remodeling. The goal of our study was to evaluate Sirt1 activity in peripheral blood mononuclear cells in patients with osteoarthritis in comparison with control patients, and to determine the relationship between Sirt1 activity and production of TNFα, IL-6 and IL-8 by peripheral blood mononuclear cells after ex vivo treatment with resveratrol, a Sirt1 activator.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 23 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 1 4%
Researcher 1 4%
Student > Postgraduate 1 4%
Student > Master 1 4%
Unknown 19 83%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 1 4%
Agricultural and Biological Sciences 1 4%
Medicine and Dentistry 1 4%
Unknown 20 87%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 September 2013.
All research outputs
#17,691,177
of 22,714,025 outputs
Outputs from Clinical Epigenetics
#923
of 1,237 outputs
Outputs of similar age
#139,537
of 194,295 outputs
Outputs of similar age from Clinical Epigenetics
#5
of 6 outputs
Altmetric has tracked 22,714,025 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,237 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.5. This one is in the 20th percentile – i.e., 20% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 194,295 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 24th percentile – i.e., 24% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one.