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High plasticity of axonal pathology in Alzheimer’s disease mouse models

Overview of attention for article published in Acta Neuropathologica Communications, February 2017
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (83rd percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

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1 news outlet
twitter
1 tweeter

Citations

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33 Dimensions

Readers on

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59 Mendeley
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Title
High plasticity of axonal pathology in Alzheimer’s disease mouse models
Published in
Acta Neuropathologica Communications, February 2017
DOI 10.1186/s40478-017-0415-y
Pubmed ID
Authors

Lidia Blazquez-Llorca, Susana Valero-Freitag, Eva Ferreira Rodrigues, Ángel Merchán-Pérez, J. Rodrigo Rodríguez, Mario M. Dorostkar, Javier DeFelipe, Jochen Herms

Abstract

Axonal dystrophies (AxDs) are swollen and tortuous neuronal processes that are associated with extracellular depositions of amyloid β (Aβ) and have been observed to contribute to synaptic alterations occurring in Alzheimer's disease. Understanding the temporal course of this axonal pathology is of high relevance to comprehend the progression of the disease over time. We performed a long-term in vivo study (up to 210 days of two-photon imaging) with two transgenic mouse models (dE9xGFP-M and APP-PS1xGFP-M). Interestingly, AxDs were formed only in a quarter of GFP-expressing axons near Aβ-plaques, which indicates a selective vulnerability. AxDs, especially those reaching larger sizes, had long lifetimes and appeared as highly plastic structures with large variations in size and shape and axonal sprouting over time. In the case of the APP-PS1 mouse only, the formation of new long axonal segments in dystrophic axons (re-growth phenomenon) was observed. Moreover, new AxDs could appear at the same point of the axon where a previous AxD had been located before disappearance (re-formation phenomenon). In addition, we observed that most AxDs were formed and developed during the imaging period, and numerous AxDs had already disappeared by the end of this time. This work is the first in vivo study analyzing quantitatively the high plasticity of the axonal pathology around Aβ plaques. We hypothesized that a therapeutically early prevention of Aβ plaque formation or their growth might halt disease progression and promote functional axon regeneration and the recovery of neural circuits.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 59 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Czechia 1 2%
Unknown 58 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 19%
Researcher 11 19%
Student > Master 11 19%
Student > Bachelor 6 10%
Student > Doctoral Student 3 5%
Other 6 10%
Unknown 11 19%
Readers by discipline Count As %
Neuroscience 19 32%
Agricultural and Biological Sciences 11 19%
Business, Management and Accounting 3 5%
Biochemistry, Genetics and Molecular Biology 3 5%
Medicine and Dentistry 3 5%
Other 6 10%
Unknown 14 24%

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 March 2017.
All research outputs
#1,062,892
of 9,176,636 outputs
Outputs from Acta Neuropathologica Communications
#119
of 448 outputs
Outputs of similar age
#52,322
of 312,682 outputs
Outputs of similar age from Acta Neuropathologica Communications
#9
of 15 outputs
Altmetric has tracked 9,176,636 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 448 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.5. This one has gotten more attention than average, scoring higher than 71% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 312,682 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.