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Hyperbaric oxygen in chronic traumatic brain injury: oxygen, pressure, and gene therapy

Overview of attention for article published in Medical Gas Research, July 2015
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  • Above-average Attention Score compared to outputs of the same age (53rd percentile)

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7 Facebook pages

Citations

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45 Mendeley
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Title
Hyperbaric oxygen in chronic traumatic brain injury: oxygen, pressure, and gene therapy
Published in
Medical Gas Research, July 2015
DOI 10.1186/s13618-015-0030-6
Pubmed ID
Authors

Paul G. Harch

Abstract

Hyperbaric oxygen therapy is a treatment for wounds in any location and of any duration that has been misunderstood for 353 years. Since 2008 it has been applied to the persistent post-concussion syndrome of mild traumatic brain injury by civilian and later military researchers with apparent conflicting results. The civilian studies are positive and the military-funded studies are a mixture of misinterpreted positive data, indeterminate data, and negative data. This has confused the medical, academic, and lay communities. The source of the confusion is a fundamental misunderstanding of the definition, principles, and mechanisms of action of hyperbaric oxygen therapy. This article argues that the traditional definition of hyperbaric oxygen therapy is arbitrary. The article establishes a scientific definition of hyperbaric oxygen therapy as a wound-healing therapy of combined increased atmospheric pressure and pressure of oxygen over ambient atmospheric pressure and pressure of oxygen whose main mechanisms of action are gene-mediated. Hyperbaric oxygen therapy exerts its wound-healing effects by expression and suppression of thousands of genes. The dominant gene actions are upregulation of trophic and anti-inflammatory genes and down-regulation of pro-inflammatory and apoptotic genes. The combination of genes affected depends on the different combinations of total pressure and pressure of oxygen. Understanding that hyperbaric oxygen therapy is a pressure and oxygen dose-dependent gene therapy allows for reconciliation of the conflicting TBI study results as outcomes of different doses of pressure and oxygen.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 45 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 2%
Unknown 44 98%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 7 16%
Student > Postgraduate 6 13%
Researcher 5 11%
Student > Ph. D. Student 4 9%
Other 3 7%
Other 8 18%
Unknown 12 27%
Readers by discipline Count As %
Medicine and Dentistry 17 38%
Psychology 2 4%
Agricultural and Biological Sciences 2 4%
Nursing and Health Professions 2 4%
Sports and Recreations 2 4%
Other 5 11%
Unknown 15 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 August 2019.
All research outputs
#13,301,612
of 22,953,506 outputs
Outputs from Medical Gas Research
#122
of 337 outputs
Outputs of similar age
#120,678
of 263,044 outputs
Outputs of similar age from Medical Gas Research
#2
of 2 outputs
Altmetric has tracked 22,953,506 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 337 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.9. This one has gotten more attention than average, scoring higher than 62% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 263,044 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one.