https://t.co/pOwhxZp6qV "Furthermore, this IFN-γ-mediated IL-6 induction via JAK/STAT was downregulated by JAKi."
https://t.co/pOwhxZoyBn "Among these JAKi, baricitinib was the most potent regulator for IFN-γ-induced IL-6 production in human neutrophils." "Our data indicate that IFN-γ upregulates IL-6 production via the JAK1/2-STAT1 pathway in human innate immune ce
https://t.co/pOwhxZp6qV "Although all JAKi, blocked IFN-γ-induced JAK1/2-STAT1 phosphorylation at higher concentrations (100 nM), baricitinib most efficiently inhibited IFN-γ-induced JAK1/2-STAT1 phosphorylation at lower concentrations (≤ 25 nM)."
Interferon-γ induces interleukin-6 production by neutrophils via the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway #IL6 #IFNγ #JAK1 #JAK2 #STAT1 #MECFS #LongCovid https://t.co/pOwhxZp6qV