Title |
Brain natriuretic peptide is not predictive of dilated cardiomyopathy in Becker and Duchenne muscular dystrophy patients and carriers
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Published in |
BMC Neurology, July 2013
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DOI | 10.1186/1471-2377-13-88 |
Pubmed ID | |
Authors |
Steven Schade van Westrum, Lukas Dekker, Rob de Haan, Erik Endert, Ieke Ginjaar, Marianne de Visser, Anneke van der Kooi |
Abstract |
Cardiomyopathy is reported in Duchenne and Becker muscle dystrophy patients and female carriers. Brain Natriuretic peptide (BNP) is a hormone produced mainly by ventricular cardiomyocytes and its production is up regulated in reaction to increased wall stretching. N-terminal-proBNP (NT-proBNP) has been shown to be a robust laboratory parameter to diagnose and monitor cardiac failure, and it may be helpful to screen for asymptomatic left ventricular dysfunction. Therefore we tested whether NT-proBNP can distinguish patients with Duchenne or Becker muscular dystrophy patients and carriers of a dystrophin mutation with a dilated cardiomyopathy from those without. |
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