Title |
Dual effects of noradrenaline on astroglial production of chemokines and pro-inflammatory mediators
|
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Published in |
Journal of Neuroinflammation, July 2013
|
DOI | 10.1186/1742-2094-10-81 |
Pubmed ID | |
Authors |
Ara E Hinojosa, Javier R Caso, Borja García-Bueno, Juan C Leza, José LM Madrigal |
Abstract |
Noradrenaline (NA) is known to limit neuroinflammation. However, the previously described induction by NA of a chemokine involved in the progression of immune/inflammatory processes, such as chemokine (C-C motif) ligand 2 (CCL2)/monocyte chemotactic protein-1 (MCP-1), apparently contradicts NA anti-inflammatory actions. In the current study we analyzed NA regulation of astroglial chemokine (C-X3-C motif) ligand 1 (CX3CL1), also known as fractalkine, another chemokine to which both neuroprotective and neurodegenerative actions have been attributed. In addition, NA effects on other chemokines and pro-inflammatory mediators were also analyzed. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 2% |
Unknown | 55 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 9 | 16% |
Student > Bachelor | 8 | 14% |
Student > Ph. D. Student | 7 | 13% |
Other | 4 | 7% |
Researcher | 4 | 7% |
Other | 13 | 23% |
Unknown | 11 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 15 | 27% |
Neuroscience | 10 | 18% |
Medicine and Dentistry | 7 | 13% |
Biochemistry, Genetics and Molecular Biology | 4 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 5% |
Other | 4 | 7% |
Unknown | 13 | 23% |