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Synovitis in osteoarthritis: current understanding with therapeutic implications

Overview of attention for article published in Arthritis Research & Therapy, February 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#38 of 3,380)
  • High Attention Score compared to outputs of the same age (97th percentile)
  • High Attention Score compared to outputs of the same age and source (97th percentile)

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Title
Synovitis in osteoarthritis: current understanding with therapeutic implications
Published in
Arthritis Research & Therapy, February 2017
DOI 10.1186/s13075-017-1229-9
Pubmed ID
Authors

Alexander Mathiessen, Philip G. Conaghan

Abstract

Modern concepts of osteoarthritis (OA) have been forever changed by modern imaging phenotypes demonstrating complex and multi-tissue pathologies involving cartilage, subchondral bone and (increasingly recognized) inflammation of the synovium. The synovium may show significant changes, even before visible cartilage degeneration has occurred, with infiltration of mononuclear cells, thickening of the synovial lining layer and production of inflammatory cytokines. The combination of sensitive imaging modalities and tissue examination has confirmed a high prevalence of synovial inflammation in all stages of OA, with a number of studies demonstrating that synovitis is related to pain, poor function and may even be an independent driver of radiographic OA onset and structural progression. Treating key aspects of synovial inflammation therefore holds great promise for analgesia and also for structure modification. This article will review current knowledge on the prevalence of synovitis in OA and its role in symptoms and structural progression, and explore lessons learnt from targeting synovitis therapeutically.

X Demographics

X Demographics

The data shown below were collected from the profiles of 47 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 739 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 <1%
Unknown 738 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 106 14%
Student > Master 106 14%
Student > Bachelor 84 11%
Researcher 69 9%
Other 38 5%
Other 107 14%
Unknown 229 31%
Readers by discipline Count As %
Medicine and Dentistry 151 20%
Biochemistry, Genetics and Molecular Biology 78 11%
Engineering 46 6%
Nursing and Health Professions 41 6%
Agricultural and Biological Sciences 39 5%
Other 119 16%
Unknown 265 36%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 76. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 August 2022.
All research outputs
#561,497
of 25,382,440 outputs
Outputs from Arthritis Research & Therapy
#38
of 3,380 outputs
Outputs of similar age
#12,265
of 424,587 outputs
Outputs of similar age from Arthritis Research & Therapy
#1
of 44 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,380 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.2. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 424,587 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 44 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.