↓ Skip to main content

Transcription factor NFκB regulates the expression of the histone deacetylase SIRT1

Overview of attention for article published in Clinical Epigenetics, July 2013
Altmetric Badge

Mentioned by

twitter
1 tweeter

Citations

dimensions_citation
29 Dimensions

Readers on

mendeley
32 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Transcription factor NFκB regulates the expression of the histone deacetylase SIRT1
Published in
Clinical Epigenetics, July 2013
DOI 10.1186/1868-7083-5-11
Pubmed ID
Authors

Judith Katto, Nicole Engel, Wasim Abbas, Georges Herbein, Ulrich Mahlknecht

Abstract

The NAD-dependent protein deacetylase SIRT1 has a wide range of different targets, which may be regulated either directly through deacetylation and thus potentially altering their activity or localization or indirectly by deacetylation of histones, which in turn alters their transcription rate and availability. SIRT1 is therefore involved in the regulation of many different and fundamental cellular processes such as apoptosis, metabolism, differentiation and cell cycle arrest. It is also involved in the regulation of resistance of cells against oxidative stress and longevity under conditions of caloric restriction. Even though the targets and role of SIRT1 have been studied quite intensively, only little is known about the mechanisms affecting SIRT1 transcriptional regulation. The nuclear factor NFκB is a well-studied and widely known transcription factor, which is involved in the regulation of many important cellular activities. The regulation of NFκB by SIRT1 has been reported recently, but it is, however, still unknown whether a feedback mechanism affects the regulation of SIRT1 too, particularly in view of the fact that putative NFκB binding sites within the SIRT1 promoter suggest just that.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 6%
Ireland 1 3%
Unknown 29 91%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 19%
Researcher 5 16%
Student > Bachelor 4 13%
Student > Master 4 13%
Professor 3 9%
Other 6 19%
Unknown 4 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 11 34%
Biochemistry, Genetics and Molecular Biology 7 22%
Medicine and Dentistry 4 13%
Immunology and Microbiology 2 6%
Environmental Science 1 3%
Other 3 9%
Unknown 4 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 July 2013.
All research outputs
#15,055,021
of 18,796,975 outputs
Outputs from Clinical Epigenetics
#804
of 1,025 outputs
Outputs of similar age
#123,481
of 170,281 outputs
Outputs of similar age from Clinical Epigenetics
#1
of 1 outputs
Altmetric has tracked 18,796,975 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,025 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.4. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 170,281 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them