Title |
Estrogen- and stress-induced DNA damage in breast cancer and chemoprevention with dietary flavonoid
|
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Published in |
Genes and Environment, February 2017
|
DOI | 10.1186/s41021-016-0071-7 |
Pubmed ID | |
Authors |
Michiko T. Yasuda, Hiroyuki Sakakibara, Kayoko Shimoi |
Abstract |
Breast cancer is one of the most commonly diagnosed female cancers and a leading cause of cancer-related death in women. Multiple factors are responsible for breast cancer and heritable factors have received much attention. DNA damage in breast cancer is induced by prolonged exposure to estrogens, such as 17β-estradiol, daily social/psychological stressors, and environmental chemicals such as polycyclic aromatic hydrocarbons (PAHs) and heterocyclic amines (HCAs). DNA damage induced by estrogen and stress is an important factor in the pathogenesis and development of breast cancer and is now recognized as a critical provision for chemoprevention of breast cancer. In this review, we summarize the relationships between estrogen- and stress-induced DNA damage with regard to the pathogenesis and development of breast cancer. We also discuss recent investigations into chemoprevention using dietary flavonoids such as quercetin and isoflavones. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 50% |
United Kingdom | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 50% |
Scientists | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 93 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 15 | 16% |
Student > Bachelor | 14 | 15% |
Researcher | 11 | 12% |
Student > Ph. D. Student | 9 | 10% |
Student > Postgraduate | 6 | 6% |
Other | 13 | 14% |
Unknown | 25 | 27% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 18 | 19% |
Medicine and Dentistry | 15 | 16% |
Nursing and Health Professions | 11 | 12% |
Agricultural and Biological Sciences | 7 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 4% |
Other | 10 | 11% |
Unknown | 28 | 30% |