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Production of hydroxycinnamoyl anthranilates from glucose in Escherichia coli

Overview of attention for article published in Microbial Cell Factories, June 2013
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#33 of 1,587)
  • High Attention Score compared to outputs of the same age (92nd percentile)
  • High Attention Score compared to outputs of the same age and source (85th percentile)

Mentioned by

news
1 news outlet
blogs
1 blog
patent
1 patent

Citations

dimensions_citation
49 Dimensions

Readers on

mendeley
87 Mendeley
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Title
Production of hydroxycinnamoyl anthranilates from glucose in Escherichia coli
Published in
Microbial Cell Factories, June 2013
DOI 10.1186/1475-2859-12-62
Pubmed ID
Authors

Aymerick Eudes, Darmawi Juminaga, Edward E K Baidoo, F William Collins, Jay D Keasling, Dominique Loqué

Abstract

Oats contain hydroxycinnamoyl anthranilates, also named avenanthramides (Avn), which have beneficial health properties because of their antioxidant, anti-inflammatory, and antiproliferative effects. The microbial production of hydroxycinnamoyl anthranilates is an eco-friendly alternative to chemical synthesis or purification from plant sources. We recently demonstrated in yeast (Saccharomyces cerevisiae) that coexpression of 4-coumarate: CoA ligase (4CL) from Arabidopsis thaliana and hydroxycinnamoyl/benzoyl-CoA/anthranilate N-hydroxycinnamoyl/benzoyltransferase (HCBT) from Dianthus caryophyllusenabled the biological production of several cinnamoyl anthranilates upon feeding with anthranilate and various cinnamates. Using engineering strategies to overproduce anthranilate and hydroxycinnamates, we describe here an entire pathway for the microbial synthesis of two Avns from glucose in Escherichia coli.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 87 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Mexico 1 1%
China 1 1%
Canada 1 1%
Unknown 84 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 25 29%
Student > Ph. D. Student 20 23%
Student > Master 7 8%
Student > Bachelor 6 7%
Professor 3 3%
Other 12 14%
Unknown 14 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 36 41%
Biochemistry, Genetics and Molecular Biology 16 18%
Environmental Science 4 5%
Engineering 4 5%
Chemistry 2 2%
Other 8 9%
Unknown 17 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 20. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 May 2021.
All research outputs
#1,543,025
of 22,714,025 outputs
Outputs from Microbial Cell Factories
#33
of 1,587 outputs
Outputs of similar age
#14,083
of 195,450 outputs
Outputs of similar age from Microbial Cell Factories
#1
of 7 outputs
Altmetric has tracked 22,714,025 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,587 research outputs from this source. They receive a mean Attention Score of 4.4. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 195,450 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them