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Kinetics of the viral cycle influence pharmacodynamics of antiretroviral therapy

Overview of attention for article published in Biology Direct, September 2011
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Title
Kinetics of the viral cycle influence pharmacodynamics of antiretroviral therapy
Published in
Biology Direct, September 2011
DOI 10.1186/1745-6150-6-42
Pubmed ID
Authors

Ahmad R Sedaghat, Claus O Wilke

Abstract

More and more antiretroviral therapies are being developed for treatment of HIV infection. The in-vivo efficacy of these drugs is commonly predicted based on in-vitro measures of antiviral effect. One primary in-vitro measure is the IC50, the amount of drug required for 50% inhibition of viral replication. We have previously shown that HIV life-cycle kinetics impact clinically observed HIV viral dynamics. Here we present a mathematical model of how they affect the pharmacodynamics of antiretroviral drugs.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Denmark 1 4%
Unknown 25 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 31%
Student > Master 4 15%
Researcher 4 15%
Student > Doctoral Student 3 12%
Student > Bachelor 2 8%
Other 2 8%
Unknown 3 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 6 23%
Engineering 4 15%
Medicine and Dentistry 3 12%
Mathematics 2 8%
Pharmacology, Toxicology and Pharmaceutical Science 2 8%
Other 6 23%
Unknown 3 12%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 July 2013.
All research outputs
#17,286,645
of 25,374,917 outputs
Outputs from Biology Direct
#386
of 537 outputs
Outputs of similar age
#97,085
of 136,926 outputs
Outputs of similar age from Biology Direct
#10
of 12 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 537 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.3. This one is in the 20th percentile – i.e., 20% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 136,926 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.