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Immunological aspects of the efficiency of protectotype vaccination strategy against chicken infectious bronchitis

Overview of attention for article published in BMC Veterinary Research, February 2017
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Title
Immunological aspects of the efficiency of protectotype vaccination strategy against chicken infectious bronchitis
Published in
BMC Veterinary Research, February 2017
DOI 10.1186/s12917-017-0963-1
Pubmed ID
Authors

Marcin Smialek, Bartlomiej Tykalowski, Daria Dziewulska, Tomasz Stenzel, Andrzej Koncicki

Abstract

One of the most commonly applied protectotype vaccination protocol against infectious bronchitis (IB) in broiler chickens in the EU is simultaneous or alternate use of Ma5 and 4/91 vaccine strains. After IB vaccination and infection, systemic and upper respiratory tract (URT), humoral and cell-mediated immunity (CMI), are stimulated. The level of this stimulation correlates with the level of protection against IB. We've investigated the development of URT and systemic, cell-mediated and humoral immunity in commercial broiler chickens vaccinated with Ma5 and/or 4/91 strains at hatch day. We've demonstrated that the group vaccinated with Ma5 and 4/91 strain simultaneously developed the most desirable immunity which reflects the level of CD8(+) T cells stimulation in spleen and Harderian gland, as well as the level of IgA and IgY in URT washings and serum and their cross-reactivity with 7 IBV strains. Although we did not demonstrate directly why Ma5 + 4/91 protocol is so efficient it seems that it combines the benefits of monovalent vaccination with either Ma5 or 4/91 and while Ma5 seems to stimulate CMI more efficiently, the 4/91 strain generates a wider spectrum of immune system cross-reactivity and higher URT IgA production.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 44 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 44 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 20%
Student > Bachelor 6 14%
Student > Master 6 14%
Student > Ph. D. Student 5 11%
Unspecified 3 7%
Other 7 16%
Unknown 8 18%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 16 36%
Agricultural and Biological Sciences 5 11%
Biochemistry, Genetics and Molecular Biology 3 7%
Unspecified 3 7%
Nursing and Health Professions 2 5%
Other 6 14%
Unknown 9 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 February 2017.
All research outputs
#20,403,545
of 22,953,506 outputs
Outputs from BMC Veterinary Research
#2,424
of 3,058 outputs
Outputs of similar age
#356,001
of 420,438 outputs
Outputs of similar age from BMC Veterinary Research
#47
of 59 outputs
Altmetric has tracked 22,953,506 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,058 research outputs from this source. They receive a mean Attention Score of 3.9. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 59 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.