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The role of mutation in the new cancer paradigm

Overview of attention for article published in Cancer Cell International, April 2005
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1 tweeter

Citations

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Title
The role of mutation in the new cancer paradigm
Published in
Cancer Cell International, April 2005
DOI 10.1186/1475-2867-5-9
Pubmed ID
Authors

Richmond T Prehn

Abstract

The almost universal belief that cancer is caused by mutation may gradually be giving way to the belief that cancer begins as a cellular adaptation that involves the local epigenetic silencing of various genes. In my own interpretation of the new epigenetic paradigm, the genes epigenetically suppressed are genes that normally serve in post-embryonic life to suppress and keep suppressed those other genes upon which embryonic development depends. Those other genes, if not silenced or suppressed in the post-embryonic animal, become, I suggest, the oncogenes that are the basis of neoplasia.Mutations that occur in silenced genes supposedly go unrepaired and are, therefore, postulated to accumulate, but such mutations probably play little or no causative role in neoplasia because they occur in already epigenetically silenced genes. These mutations probably often serve to make the silencing, and therefore the cancer, epigenetically irreversible.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 6%
Unknown 15 94%

Demographic breakdown

Readers by professional status Count As %
Professor > Associate Professor 6 38%
Student > Ph. D. Student 6 38%
Professor 1 6%
Student > Bachelor 1 6%
Student > Master 1 6%
Other 1 6%
Readers by discipline Count As %
Agricultural and Biological Sciences 6 38%
Medicine and Dentistry 4 25%
Mathematics 2 13%
Biochemistry, Genetics and Molecular Biology 2 13%
Immunology and Microbiology 1 6%
Other 1 6%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 July 2013.
All research outputs
#18,341,711
of 22,714,025 outputs
Outputs from Cancer Cell International
#1,076
of 1,789 outputs
Outputs of similar age
#54,607
of 57,853 outputs
Outputs of similar age from Cancer Cell International
#2
of 2 outputs
Altmetric has tracked 22,714,025 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,789 research outputs from this source. They receive a mean Attention Score of 3.8. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 57,853 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 2nd percentile – i.e., 2% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one.