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Genes of the RNASE5 pathway contain SNP associated with milk production traits in dairy cattle

Overview of attention for article published in Genetics Selection Evolution, July 2013
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Title
Genes of the RNASE5 pathway contain SNP associated with milk production traits in dairy cattle
Published in
Genetics Selection Evolution, July 2013
DOI 10.1186/1297-9686-45-25
Pubmed ID
Authors

Lesley-Ann Raven, Benjamin G Cocks, Jennie E Pryce, Jeremy J Cottrell, Ben J Hayes

Abstract

Identification of the processes and mutations responsible for the large genetic variation in milk production among dairy cattle has proved challenging. One approach is to identify a biological process potentially involved in milk production and to determine the genetic influence of all the genes included in the process or pathway. Angiogenin encoded by angiogenin, ribonuclease, RNase A family 5 (RNASE5) is relatively abundant in milk, and has been shown to regulate protein synthesis and act as a growth factor in epithelial cells in vitro. However, little is known about the role of angiogenin in the mammary gland or if the polymorphisms present in the bovine RNASE5 gene are associated with lactation and milk production traits in dairy cattle. Given the high economic value of increased protein in milk, we have tested the hypothesis that RNASE5 or genes in the RNASE5 pathway are associated with milk production traits. First, we constructed a "RNASE5 pathway" based on upstream and downstream interacting genes reported in the literature. We then tested SNP in close proximity to the genes of this pathway for association with milk production traits in a large dairy cattle dataset.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Korea, Republic of 1 4%
United States 1 4%
Unknown 25 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 37%
Student > Bachelor 3 11%
Student > Master 3 11%
Researcher 3 11%
Professor 3 11%
Other 1 4%
Unknown 4 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 16 59%
Veterinary Science and Veterinary Medicine 3 11%
Biochemistry, Genetics and Molecular Biology 3 11%
Medicine and Dentistry 1 4%
Unknown 4 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 July 2013.
All research outputs
#9,961,784
of 12,443,702 outputs
Outputs from Genetics Selection Evolution
#329
of 435 outputs
Outputs of similar age
#104,284
of 151,466 outputs
Outputs of similar age from Genetics Selection Evolution
#3
of 4 outputs
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