Title |
The advantages and limitations of trait analysis with GWAS: a review
|
---|---|
Published in |
Plant Methods, July 2013
|
DOI | 10.1186/1746-4811-9-29 |
Pubmed ID | |
Authors |
Arthur Korte, Ashley Farlow |
Abstract |
Over the last 10 years, high-density SNP arrays and DNA re-sequencing have illuminated the majority of the genotypic space for a number of organisms, including humans, maize, rice and Arabidopsis. For any researcher willing to define and score a phenotype across many individuals, Genome Wide Association Studies (GWAS) present a powerful tool to reconnect this trait back to its underlying genetics. In this review we discuss the biological and statistical considerations that underpin a successful analysis or otherwise. The relevance of biological factors including effect size, sample size, genetic heterogeneity, genomic confounding, linkage disequilibrium and spurious association, and statistical tools to account for these are presented. GWAS can offer a valuable first insight into trait architecture or candidate loci for subsequent validation. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 5 | 71% |
United States | 1 | 14% |
Unknown | 1 | 14% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 5 | 71% |
Science communicators (journalists, bloggers, editors) | 1 | 14% |
Scientists | 1 | 14% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 16 | <1% |
France | 9 | <1% |
Brazil | 9 | <1% |
United Kingdom | 7 | <1% |
Germany | 6 | <1% |
Netherlands | 3 | <1% |
Chile | 2 | <1% |
Colombia | 2 | <1% |
Italy | 2 | <1% |
Other | 27 | 1% |
Unknown | 1971 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 526 | 26% |
Researcher | 326 | 16% |
Student > Master | 308 | 15% |
Student > Bachelor | 170 | 8% |
Student > Doctoral Student | 114 | 6% |
Other | 229 | 11% |
Unknown | 381 | 19% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 270 | 13% |
Computer Science | 43 | 2% |
Medicine and Dentistry | 29 | 1% |
Environmental Science | 25 | 1% |
Other | 119 | 6% |
Unknown | 430 | 21% |