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Enhancing circadian clock function in cancer cells inhibits tumor growth

Overview of attention for article published in BMC Biology, February 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#17 of 1,685)
  • High Attention Score compared to outputs of the same age (99th percentile)

Mentioned by

news
20 news outlets
blogs
2 blogs
twitter
80 tweeters
facebook
8 Facebook pages
wikipedia
1 Wikipedia page
googleplus
2 Google+ users

Citations

dimensions_citation
98 Dimensions

Readers on

mendeley
190 Mendeley
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Title
Enhancing circadian clock function in cancer cells inhibits tumor growth
Published in
BMC Biology, February 2017
DOI 10.1186/s12915-017-0349-7
Pubmed ID
Authors

Silke Kiessling, Lou Beaulieu-Laroche, Ian D. Blum, Dominic Landgraf, David K. Welsh, Kai-Florian Storch, Nathalie Labrecque, Nicolas Cermakian

Abstract

Circadian clocks control cell cycle factors, and circadian disruption promotes cancer. To address whether enhancing circadian rhythmicity in tumor cells affects cell cycle progression and reduces proliferation, we compared growth and cell cycle events of B16 melanoma cells and tumors with either a functional or dysfunctional clock. We found that clock genes were suppressed in B16 cells and tumors, but treatments inducing circadian rhythmicity, such as dexamethasone, forskolin and heat shock, triggered rhythmic clock and cell cycle gene expression, which resulted in fewer cells in S phase and more in G1 phase. Accordingly, B16 proliferation in vitro and tumor growth in vivo was slowed down. Similar effects were observed in human colon carcinoma HCT-116 cells. Notably, the effects of dexamethasone were not due to an increase in apoptosis nor to an enhancement of immune cell recruitment to the tumor. Knocking down the essential clock gene Bmal1 in B16 tumors prevented the effects of dexamethasone on tumor growth and cell cycle events. Here we demonstrated that the effects of dexamethasone on cell cycle and tumor growth are mediated by the tumor-intrinsic circadian clock. Thus, our work reveals that enhancing circadian clock function might represent a novel strategy to control cancer progression.

Twitter Demographics

The data shown below were collected from the profiles of 80 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 190 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
China 1 <1%
Belgium 1 <1%
Unknown 188 99%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 46 24%
Student > Ph. D. Student 33 17%
Researcher 27 14%
Student > Master 25 13%
Student > Postgraduate 8 4%
Other 25 13%
Unknown 26 14%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 71 37%
Agricultural and Biological Sciences 30 16%
Medicine and Dentistry 16 8%
Neuroscience 10 5%
Pharmacology, Toxicology and Pharmaceutical Science 5 3%
Other 21 11%
Unknown 37 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 220. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 November 2021.
All research outputs
#109,082
of 19,541,023 outputs
Outputs from BMC Biology
#17
of 1,685 outputs
Outputs of similar age
#4,054
of 431,127 outputs
Outputs of similar age from BMC Biology
#1
of 1 outputs
Altmetric has tracked 19,541,023 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,685 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.1. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 431,127 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them