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Comparison of virulence of Francisella tularensis ssp. holarctica genotypes B.12 and B.FTNF002-00

Overview of attention for article published in BMC Veterinary Research, February 2017
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Title
Comparison of virulence of Francisella tularensis ssp. holarctica genotypes B.12 and B.FTNF002-00
Published in
BMC Veterinary Research, February 2017
DOI 10.1186/s12917-017-0968-9
Pubmed ID
Authors

Zsuzsa Kreizinger, Károly Erdélyi, Orsolya Felde, Massimo Fabbi, Kinga M. Sulyok, Tibor Magyar, Miklós Gyuranecz

Abstract

Two main genetic groups (B.12 and B.FTNF002-00) of Francisella tularensis ssp. holarctica are endemic in Europe. The B.FTNF002-00 group proved to be dominant in Western European countries, while strains of the B.12 group were isolated mainly in Northern, Central and Eastern Europe. The clinical course of tularemia in the European brown hare (Lepus europaeus) also shows distinct patterns according to the geographical area. Acute course of the disease is observed in hares in Western European countries, while signs of sub-acute or chronic infection are more frequently detected in the eastern part of the continent. The aim of the present study was to examine whether there is any difference in the virulence of the strains belonging to the B.FTNF002-00 and B.12 genetic clades. Experimental infection of Fischer 344 rats was performed by intra-peritoneal injection of three dilutions of a Hungarian (B.12 genotype) and an Italian (B.FTNF002-00 genotype) F. tularensis ssp. holarctica strain. Moderate difference was observed in the virulence of the two genotypes. Significant differences were observed in total weight loss values and scores of clinical signs between the two genotypes with more rats succumbing to tularemia in groups infected with the B.FTNF002-00 genotype. Results of the experimental infection are consistent with previous clinical observations and pathological studies suggesting that F. tularensis ssp. holarctica genotype B.FTNF002-00 has higher pathogenic potential than the B.12 genotype.

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Geographical breakdown

Country Count As %
Sweden 1 6%
Unknown 17 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 33%
Student > Ph. D. Student 5 28%
Student > Bachelor 1 6%
Professor 1 6%
Student > Master 1 6%
Other 1 6%
Unknown 3 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 4 22%
Biochemistry, Genetics and Molecular Biology 3 17%
Veterinary Science and Veterinary Medicine 3 17%
Nursing and Health Professions 1 6%
Neuroscience 1 6%
Other 0 0%
Unknown 6 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 February 2017.
All research outputs
#20,403,545
of 22,953,506 outputs
Outputs from BMC Veterinary Research
#2,424
of 3,058 outputs
Outputs of similar age
#357,924
of 422,694 outputs
Outputs of similar age from BMC Veterinary Research
#48
of 60 outputs
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