↓ Skip to main content

Intra-articular delivery of adipose derived stromal cells attenuates osteoarthritis progression in an experimental rabbit model

Overview of attention for article published in Arthritis Research & Therapy, January 2013
Altmetric Badge

About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (89th percentile)
  • High Attention Score compared to outputs of the same age and source (86th percentile)

Citations

dimensions_citation
176 Dimensions

Readers on

mendeley
171 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Intra-articular delivery of adipose derived stromal cells attenuates osteoarthritis progression in an experimental rabbit model
Published in
Arthritis Research & Therapy, January 2013
DOI 10.1186/ar4156
Pubmed ID
Authors

Giovanna Desando, Carola Cavallo, Federica Sartoni, Lucia Martini, Annapaola Parrilli, Francesca Veronesi, Milena Fini, Roberto Giardino, Andrea Facchini, Brunella Grigolo

Abstract

INTRODUCTION: Cell therapy is a rapidly growing area of research for the treatment of osteoarthritis (OA). This work is aimed to investigate the efficacy of intra-articular adipose-derived stromal cell (ASC) injection in the healing process on cartilage, synovial membrane and menisci in an experimental rabbit model. METHODS: The induction of OA was performed surgically through bilateral anterior cruciate ligament transection (ACLT) to achieve eight weeks from ACLT a mild grade of OA. A total of 2 × 106 and 6 × 106 autologous ASCs isolated from inguinal fat, expanded in vitro and suspended in 4% rabbit serum albumin (RSA) were delivered in the hind limbs; 4% RSA was used as the control. Local bio-distribution of the cells was verified by injecting chloro-methyl-benzamido-1,1'-dioctadecyl-3,3,3'3'-tetra-methyl-indo-carbocyanine per-chlorate (CM-Dil) labeled ASCs in the hind limbs. Cartilage and synovial histological sections were scored by Laverty's scoring system to assess the severity of the pathology. Protein expression of some extracellular matrix molecules (collagen I and II), catabolic (metalloproteinase-1 and -3) and inflammatory (tumor necrosis factor- α) markers were detected by immunohistochemistry. Assessments were carried out at 16 and 24 weeks. RESULTS: Labeled-ASCs were detected unexpectedly in the synovial membrane and medial meniscus but not in cartilage tissue at 3 and 20 days from ASC-treatment. Intra-articular ASC administration decreases OA progression and exerts a healing contribution in the treated animals in comparison to OA and 4% RSA groups. CONCLUSIONS: Our data reveal a healing capacity of ASCs in promoting cartilage and menisci repair and attenuating inflammatory events in synovial membrane inhibiting OA progression. On the basis of the local bio-distribution findings, the benefits obtained by ASC treatment could be due to a trophic mechanism of action by the release of growth factors and cytokines.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 171 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 2 1%
Japan 1 <1%
Italy 1 <1%
Denmark 1 <1%
Unknown 166 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 32 19%
Student > Ph. D. Student 27 16%
Student > Master 27 16%
Student > Bachelor 18 11%
Other 11 6%
Other 25 15%
Unknown 31 18%
Readers by discipline Count As %
Medicine and Dentistry 42 25%
Agricultural and Biological Sciences 31 18%
Biochemistry, Genetics and Molecular Biology 25 15%
Engineering 8 5%
Immunology and Microbiology 6 4%
Other 20 12%
Unknown 39 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 August 2023.
All research outputs
#3,141,455
of 25,394,764 outputs
Outputs from Arthritis Research & Therapy
#642
of 3,382 outputs
Outputs of similar age
#30,912
of 290,891 outputs
Outputs of similar age from Arthritis Research & Therapy
#6
of 43 outputs
Altmetric has tracked 25,394,764 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,382 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.2. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 290,891 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 43 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.