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The role of exosomes in the pathogenesis of Alzheimer’ disease

Overview of attention for article published in Translational Neurodegeneration, February 2017
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#34 of 100)
  • Good Attention Score compared to outputs of the same age (75th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (60th percentile)

Mentioned by

news
1 news outlet

Citations

dimensions_citation
82 Dimensions

Readers on

mendeley
184 Mendeley
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Title
The role of exosomes in the pathogenesis of Alzheimer’ disease
Published in
Translational Neurodegeneration, February 2017
DOI 10.1186/s40035-017-0072-x
Pubmed ID
Authors

Tingting Xiao, Weiwei Zhang, Bin Jiao, Chu-Zheng Pan, Xixi Liu, Lu Shen

Abstract

Exosomes are small vesicles secreted by most cell types including neurons that function in intercellular communication through transfer of their cargo or encapsulate and eliminate unnecessary cellular components and therefore have a broad impact on nerve development, activation and regeneration. In addition, exosomes have been observed to be involved in spreading pathological misfolded proteins, thereby leading to the onset and propagation of disease. Alzheimer disease (AD) is the most common form of dementia and characterized by two types of lesions: amyloid plaques and neurofibrillary tangles. Accumulating evidence has demonstrated that exosomes are associated with amyloid precursor (APP) and Tau proteins and play a controversial role in Alzheimer's disease process. In this review, we will discuss the role of exosomes in the metabolism and secretion of APP and Tau proteins and their subsequent impact on AD pathogenesis.

Mendeley readers

The data shown below were compiled from readership statistics for 184 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 <1%
Unknown 183 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 32 17%
Researcher 32 17%
Student > Master 29 16%
Student > Bachelor 28 15%
Student > Postgraduate 6 3%
Other 24 13%
Unknown 33 18%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 38 21%
Agricultural and Biological Sciences 33 18%
Neuroscience 29 16%
Medicine and Dentistry 15 8%
Pharmacology, Toxicology and Pharmaceutical Science 7 4%
Other 21 11%
Unknown 41 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 February 2017.
All research outputs
#1,385,136
of 9,075,481 outputs
Outputs from Translational Neurodegeneration
#34
of 100 outputs
Outputs of similar age
#58,966
of 253,680 outputs
Outputs of similar age from Translational Neurodegeneration
#2
of 5 outputs
Altmetric has tracked 9,075,481 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 100 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 30.1. This one has gotten more attention than average, scoring higher than 57% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 253,680 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 75% of its contemporaries.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.