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Multiplicity of cerebrospinal fluid functions: New challenges in health and disease

Overview of attention for article published in Cerebrospinal Fluid Research, May 2008
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (74th percentile)

Mentioned by

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6 tweeters
facebook
1 Facebook page

Citations

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614 Dimensions

Readers on

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632 Mendeley
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1 Connotea
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Title
Multiplicity of cerebrospinal fluid functions: New challenges in health and disease
Published in
Cerebrospinal Fluid Research, May 2008
DOI 10.1186/1743-8454-5-10
Pubmed ID
Authors

Conrad E Johanson, John A Duncan, Petra M Klinge, Thomas Brinker, Edward G Stopa, Gerald D Silverberg

Abstract

This review integrates eight aspects of cerebrospinal fluid (CSF) circulatory dynamics: formation rate, pressure, flow, volume, turnover rate, composition, recycling and reabsorption. Novel ways to modulate CSF formation emanate from recent analyses of choroid plexus transcription factors (E2F5), ion transporters (NaHCO3 cotransport), transport enzymes (isoforms of carbonic anhydrase), aquaporin 1 regulation, and plasticity of receptors for fluid-regulating neuropeptides. A greater appreciation of CSF pressure (CSFP) is being generated by fresh insights on peptidergic regulatory servomechanisms, the role of dysfunctional ependyma and circumventricular organs in causing congenital hydrocephalus, and the clinical use of algorithms to delineate CSFP waveforms for diagnostic and prognostic utility. Increasing attention focuses on CSF flow: how it impacts cerebral metabolism and hemodynamics, neural stem cell progression in the subventricular zone, and catabolite/peptide clearance from the CNS. The pathophysiological significance of changes in CSF volume is assessed from the respective viewpoints of hemodynamics (choroid plexus blood flow and pulsatility), hydrodynamics (choroidal hypo- and hypersecretion) and neuroendocrine factors (i.e., coordinated regulation by atrial natriuretic peptide, arginine vasopressin and basic fibroblast growth factor). In aging, normal pressure hydrocephalus and Alzheimer's disease, the expanding CSF space reduces the CSF turnover rate, thus compromising the CSF sink action to clear harmful metabolites (e.g., amyloid) from the CNS. Dwindling CSF dynamics greatly harms the interstitial environment of neurons. Accordingly the altered CSF composition in neurodegenerative diseases and senescence, because of adverse effects on neural processes and cognition, needs more effective clinical management. CSF recycling between subarachnoid space, brain and ventricles promotes interstitial fluid (ISF) convection with both trophic and excretory benefits. Finally, CSF reabsorption via multiple pathways (olfactory and spinal arachnoidal bulk flow) is likely complemented by fluid clearance across capillary walls (aquaporin 4) and arachnoid villi when CSFP and fluid retention are markedly elevated. A model is presented that links CSF and ISF homeostasis to coordinated fluxes of water and solutes at both the blood-CSF and blood-brain transport interfaces.

Twitter Demographics

The data shown below were collected from the profiles of 6 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 632 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 7 1%
United States 4 <1%
Netherlands 2 <1%
Japan 2 <1%
India 2 <1%
Switzerland 1 <1%
South Africa 1 <1%
France 1 <1%
Austria 1 <1%
Other 10 2%
Unknown 601 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 116 18%
Researcher 107 17%
Student > Bachelor 72 11%
Student > Master 57 9%
Other 39 6%
Other 159 25%
Unknown 82 13%
Readers by discipline Count As %
Medicine and Dentistry 152 24%
Agricultural and Biological Sciences 128 20%
Neuroscience 80 13%
Engineering 48 8%
Biochemistry, Genetics and Molecular Biology 32 5%
Other 93 15%
Unknown 99 16%

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 May 2014.
All research outputs
#5,539,007
of 21,347,688 outputs
Outputs from Cerebrospinal Fluid Research
#4
of 38 outputs
Outputs of similar age
#44,783
of 176,655 outputs
Outputs of similar age from Cerebrospinal Fluid Research
#1
of 1 outputs
Altmetric has tracked 21,347,688 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 38 research outputs from this source. They receive a mean Attention Score of 4.2. This one scored the same or higher as 34 of them.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 176,655 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them