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Milk is not just food but most likely a genetic transfection system activating mTORC1 signaling for postnatal growth

Overview of attention for article published in Nutrition Journal, July 2013
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (97th percentile)

Mentioned by

news
2 news outlets
blogs
1 blog
twitter
51 tweeters
facebook
20 Facebook pages
googleplus
2 Google+ users
reddit
1 Redditor
q&a
1 Q&A thread
video
10 video uploaders

Citations

dimensions_citation
134 Dimensions

Readers on

mendeley
240 Mendeley
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Title
Milk is not just food but most likely a genetic transfection system activating mTORC1 signaling for postnatal growth
Published in
Nutrition Journal, July 2013
DOI 10.1186/1475-2891-12-103
Pubmed ID
Authors

Bodo C Melnik, Swen Malte John, Gerd Schmitz

Abstract

Milk has been recognized to represent a functionally active nutrient system promoting neonatal growth of mammals. Cell growth is regulated by the nutrient-sensitive kinase mechanistic target of rapamycin complex 1 (mTORC1). There is still a lack of information on the mechanisms of mTORC1 up-regulation by milk consumption. This review presents milk as a materno-neonatal relay system functioning by transfer of preferential amino acids, which increase plasma levels of glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1), insulin, growth hormone (GH) and insulin-like growth factor-1 (IGF-1) for mTORC1 activation. Importantly, milk exosomes, which regularly contain microRNA-21, most likely represent a genetic transfection system enhancing mTORC1-driven metabolic processes. Whereas human breast milk is the ideal food for infants allowing appropriate postnatal growth and species-specific metabolic programming, persistent high milk signaling during adolescence and adulthood by continued cow´s milk consumption may promote mTORC1-driven diseases of civilization.

Twitter Demographics

The data shown below were collected from the profiles of 51 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 240 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 2 <1%
Portugal 1 <1%
Germany 1 <1%
France 1 <1%
United Kingdom 1 <1%
Canada 1 <1%
Unknown 233 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 52 22%
Student > Master 37 15%
Student > Bachelor 35 15%
Student > Ph. D. Student 32 13%
Other 16 7%
Other 43 18%
Unknown 25 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 74 31%
Medicine and Dentistry 51 21%
Biochemistry, Genetics and Molecular Biology 33 14%
Nursing and Health Professions 27 11%
Veterinary Science and Veterinary Medicine 4 2%
Other 22 9%
Unknown 29 12%

Attention Score in Context

This research output has an Altmetric Attention Score of 72. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 June 2019.
All research outputs
#405,135
of 19,449,371 outputs
Outputs from Nutrition Journal
#126
of 1,349 outputs
Outputs of similar age
#3,512
of 171,661 outputs
Outputs of similar age from Nutrition Journal
#1
of 1 outputs
Altmetric has tracked 19,449,371 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,349 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 31.4. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 171,661 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them