Title |
The spermatozoa caught in the net: the biological networks to study the male gametes post-ejaculatory life
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Published in |
BMC Systems Biology, June 2010
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DOI | 10.1186/1752-0509-4-87 |
Pubmed ID | |
Authors |
Nicola Bernabò, Mauro Mattioli, Barbara Barboni |
Abstract |
Mammalian spermatozoa, immediately after the ejaculation are unable to fertilize the oocyte. To reach their fertilizing ability the male gametes must complete a process of functional maturation, the capacitation, within the female genital tract. Only once the capacitation is completed the spermatozoa can respond to the oocyte interaction with the exocytosis of acrosome content, acrosome reaction (AR). These post-ejaculatory events are under the attention of Researchers from more than fifty years but their basic knowledge is still unsatisfactory. This failure could be due not to the insufficiency of available data, but to the inability to manage them in a descriptive model. Thus, to overlap this problem, the capacitation and the AR were represented using the biological networks formalism. In addition the effect of elimination from both the networks of the most linked (the hubs) or of random selected nodes was verified and the network representing the common element of capacitation and AR (C intersectionA) was realized. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | 3% |
Italy | 1 | 3% |
Unknown | 32 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 10 | 29% |
Researcher | 9 | 26% |
Student > Doctoral Student | 3 | 9% |
Student > Master | 3 | 9% |
Other | 2 | 6% |
Other | 1 | 3% |
Unknown | 6 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 11 | 32% |
Biochemistry, Genetics and Molecular Biology | 6 | 18% |
Veterinary Science and Veterinary Medicine | 4 | 12% |
Computer Science | 2 | 6% |
Immunology and Microbiology | 2 | 6% |
Other | 2 | 6% |
Unknown | 7 | 21% |