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The social brain network in 22q11.2 deletion syndrome: a diffusion tensor imaging study

Overview of attention for article published in Behavioral and Brain Functions, February 2017
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  • Above-average Attention Score compared to outputs of the same age (60th percentile)

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6 X users
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2 Facebook pages

Citations

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83 Mendeley
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Title
The social brain network in 22q11.2 deletion syndrome: a diffusion tensor imaging study
Published in
Behavioral and Brain Functions, February 2017
DOI 10.1186/s12993-017-0122-7
Pubmed ID
Authors

Amy K. Olszewski, Zora Kikinis, Christie S. Gonzalez, Ioana L. Coman, Nikolaos Makris, Xue Gong, Yogesh Rathi, Anni Zhu, Kevin M. Antshel, Wanda Fremont, Marek R. Kubicki, Sylvain Bouix, Martha E. Shenton, Wendy R. Kates

Abstract

Chromosome 22q11.2 deletion syndrome (22q11.2DS) is a neurogenetic disorder that is associated with a 25-fold increase in schizophrenia. Both individuals with 22q11.2DS and those with schizophrenia present with social cognitive deficits, which are putatively subserved by a network of brain regions that are involved in the processing of social cognitive information. This study used two-tensor tractography to examine the white matter tracts believed to underlie the social brain network in a group of 57 young adults with 22q11.2DS compared to 30 unaffected controls. Results indicated that relative to controls, participants with 22q11.2DS showed significant differences in several DTI metrics within the inferior fronto-occipital fasciculus, cingulum bundle, thalamo-frontal tract, and inferior longitudinal fasciculus. In addition, participants with 22q11.2DS showed significant differences in scores on measures of social cognition, including the Social Responsiveness Scale and Trait Emotional Intelligence Questionnaire. Further analyses among individuals with 22q11.2DS demonstrated an association between DTI metrics and positive and negative symptoms of psychosis, as well as differentiation between individuals with 22q11.2DS and overt psychosis, relative to those with positive prodromal symptoms or no psychosis. Findings suggest that white matter disruption, specifically disrupted axonal coherence in the right inferior fronto-occipital fasciculus, may be a biomarker for social cognitive difficulties and psychosis in individuals with 22q11.2DS.

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X Demographics

The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 83 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 1%
Australia 1 1%
Unknown 81 98%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 14 17%
Student > Ph. D. Student 13 16%
Student > Master 13 16%
Researcher 10 12%
Other 4 5%
Other 11 13%
Unknown 18 22%
Readers by discipline Count As %
Psychology 21 25%
Medicine and Dentistry 13 16%
Neuroscience 10 12%
Nursing and Health Professions 4 5%
Computer Science 3 4%
Other 7 8%
Unknown 25 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 August 2017.
All research outputs
#7,463,997
of 22,955,959 outputs
Outputs from Behavioral and Brain Functions
#137
of 392 outputs
Outputs of similar age
#119,211
of 307,002 outputs
Outputs of similar age from Behavioral and Brain Functions
#3
of 4 outputs
Altmetric has tracked 22,955,959 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 392 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.9. This one has gotten more attention than average, scoring higher than 65% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 307,002 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one.