Title |
Bioassay-guided evaluation of Dioscorea villosa – an acute and subchronic toxicity, antinociceptive and anti-inflammatory approach
|
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Published in |
BMC Complementary Medicine and Therapies, July 2013
|
DOI | 10.1186/1472-6882-13-195 |
Pubmed ID | |
Authors |
Claudio Moreira Lima, Adriana Karla Lima, Marcelia G Dória Melo, Mairim Russo Serafini, Dênisson Lima Oliveira, Enrik Barbosa de Almeida, Rosana Souza Siqueira Barreto, Paulo Cesar de Lima Nogueira, Valéria Regina de Souza Moraes, Édica Ramone Andrade Oliveira, Ricardo Luiz Cavalcanti de Albuquerque Jr, Lucindo J Quintans-Júnior, Adriano Antunes \Souza Araújo |
Abstract |
Dioscorea villosa (DV) has been used in Brazil as an alternative medicine to attenuate menopause symptoms, as well as for the treatment of joint pain and rheumatoid arthritis. In spite of the popular use of DV for the treatment of various disorders, there are limited scientific data regarding safety aspects of this herb. In this regard, we carried out to evaluated both antinociceptive and anti-inflammatory activities in experimental models and assess the toxic effects of the acute (single dose) and subchronic (30 days) oral administration of dry extract of Dioscorea villosa in rodents. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Romania | 1 | 2% |
Unknown | 57 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 8 | 14% |
Student > Bachelor | 7 | 12% |
Student > Doctoral Student | 5 | 9% |
Other | 4 | 7% |
Student > Ph. D. Student | 3 | 5% |
Other | 4 | 7% |
Unknown | 27 | 47% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 9 | 16% |
Agricultural and Biological Sciences | 7 | 12% |
Nursing and Health Professions | 4 | 7% |
Biochemistry, Genetics and Molecular Biology | 4 | 7% |
Arts and Humanities | 1 | 2% |
Other | 6 | 10% |
Unknown | 27 | 47% |