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Mendeley readers
| Title |
The buccohypophyseal canal is an ancestral vertebrate trait maintained by modulation in sonic hedgehog signaling
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|---|---|
| Published in |
BMC Biology, March 2013
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| DOI | 10.1186/1741-7007-11-27 |
| Pubmed ID | |
| Authors |
Roman H Khonsari, Maisa Seppala, Alan Pradel, Hugo Dutel, Gaël Clément, Oleg Lebedev, Sarah Ghafoor, Michaela Rothova, Abigael Tucker, John G Maisey, Chen-Ming Fan, Maiko Kawasaki, Atsushi Ohazama, Paul Tafforeau, Brunella Franco, Jill Helms, Courtney J Haycraft, Albert David, Philippe Janvier, Martyn T Cobourne, Paul T Sharpe |
| Abstract |
The pituitary gland is formed by the juxtaposition of two tissues: neuroectoderm arising from the basal diencephalon, and oral epithelium, which invaginates towards the central nervous system from the roof of the mouth. The oral invagination that reaches the brain from the mouth is referred to as Rathke's pouch, with the tip forming the adenohypophysis and the stalk disappearing after the earliest stages of development. In tetrapods, formation of the cranial base establishes a definitive barrier between the pituitary and oral cavity; however, numerous extinct and extant vertebrate species retain an open buccohypophyseal canal in adulthood, a vestige of the stalk of Rathke's pouch. Little is currently known about the formation and function of this structure. Here we have investigated molecular mechanisms driving the formation of the buccohypophyseal canal and their evolutionary significance. |
Mendeley readers
The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 4% |
| France | 1 | 2% |
| Unknown | 49 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 17 | 33% |
| Researcher | 9 | 17% |
| Student > Bachelor | 6 | 12% |
| Student > Master | 5 | 10% |
| Lecturer > Senior Lecturer | 3 | 6% |
| Other | 8 | 15% |
| Unknown | 4 | 8% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 24 | 46% |
| Biochemistry, Genetics and Molecular Biology | 9 | 17% |
| Earth and Planetary Sciences | 5 | 10% |
| Chemistry | 3 | 6% |
| Medicine and Dentistry | 2 | 4% |
| Other | 3 | 6% |
| Unknown | 6 | 12% |