Title |
Segmental duplications in the silkworm genome
|
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Published in |
BMC Genomics, July 2013
|
DOI | 10.1186/1471-2164-14-521 |
Pubmed ID | |
Authors |
Qian Zhao, Zhenglin Zhu, Masahiro Kasahara, Shinichi Morishita, Ze Zhang |
Abstract |
Segmental duplications (SDs) or low-copy repeats play important roles in both gene and genome evolution. SDs have been extensively investigated in many organisms, however, there is no information about SDs in the silkworm, Bombyx mori.Result: In this study, we identified and annotated the SDs in the silkworm genome. Our results suggested that SDs constitute ~1.4% of the silkworm genome sequence (>=1 kb in length and >=90% in the identity of sequence); the number is similar to that in Drosophila melanogaster but smaller than mammalian organisms. Almost half (42%) of the SD sequences are not assigned to chromosomes, indicating that the SDs are challenges for the assembling of genome sequences. We also provided experimental validation of large duplications using qPCR. The analysis of SD content indicated that the genes related to immunity, detoxification, reproduction, and environmental signal recognition are significantly enriched in the silkworm SDs. |
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Unknown | 2 | 100% |
Demographic breakdown
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Members of the public | 1 | 50% |
Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Mendeley readers
Geographical breakdown
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Japan | 1 | 3% |
Unknown | 28 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 10 | 34% |
Student > Doctoral Student | 4 | 14% |
Professor > Associate Professor | 3 | 10% |
Student > Bachelor | 2 | 7% |
Professor | 2 | 7% |
Other | 4 | 14% |
Unknown | 4 | 14% |
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Agricultural and Biological Sciences | 13 | 45% |
Biochemistry, Genetics and Molecular Biology | 7 | 24% |
Computer Science | 1 | 3% |
Social Sciences | 1 | 3% |
Unknown | 7 | 24% |