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High-cholesterol diet does not alter gut microbiota composition in mice

Overview of attention for article published in Nutrition & Metabolism, February 2017
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (77th percentile)
  • Good Attention Score compared to outputs of the same age and source (65th percentile)

Mentioned by

blogs
1 blog
twitter
1 tweeter
facebook
1 Facebook page

Citations

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25 Dimensions

Readers on

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63 Mendeley
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Title
High-cholesterol diet does not alter gut microbiota composition in mice
Published in
Nutrition & Metabolism, February 2017
DOI 10.1186/s12986-017-0170-x
Pubmed ID
Authors

Lidiya G. Dimova, Nikola Zlatkov, Henkjan J. Verkade, Bernt Eric Uhlin, Uwe J. F. Tietge

Abstract

Western diet containing both saturated fat and cholesterol impairs cardio-metabolic health partly by modulating diversity and function of the microbiota. While diet containing only high fat has comparable effects, it is unclear how diets only enriched in cholesterol impact the microbiota. Therefore, we aimed to characterize the response of host and microbiota to a high cholesterol (HC) diet in mice susceptible to cardio-metabolic disease. LDLR knockout mice received either 1.25% HC or no cholesterol containing control diet (NC) for 12 weeks before characterizing host cholesterol metabolism and intestinal microbiota composition (next generation sequencing). HC diet substantially increased plasma (1.6-fold) and liver cholesterol levels (21-fold), biliary cholesterol secretion (4.5-fold) and fecal neutral sterol excretion (68-fold, each p < 0.001) but not fecal bile acid excretion. Interestingly, despite the profound changes in intestinal cholesterol homeostasis no differences in microbial composition between control and HC-fed mice were detected. In both groups the main phyla were Bacteroidetes (55%), Firmicutes (27%) and Verrucomicrobia (14%). Our results demonstrate that in mice HC diet alone does not alter the microbiota composition despite inducing substantial adaptive changes in whole body cholesterol homeostasis. The impact of Western diet on intestinal microbiota thus appears to be mediated exclusively by its high fat content.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 63 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 63 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 14 22%
Student > Ph. D. Student 11 17%
Researcher 10 16%
Student > Bachelor 5 8%
Student > Doctoral Student 4 6%
Other 10 16%
Unknown 9 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 15 24%
Medicine and Dentistry 9 14%
Biochemistry, Genetics and Molecular Biology 9 14%
Immunology and Microbiology 6 10%
Nursing and Health Professions 3 5%
Other 5 8%
Unknown 16 25%

Attention Score in Context

This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 July 2017.
All research outputs
#1,602,283
of 11,437,561 outputs
Outputs from Nutrition & Metabolism
#219
of 595 outputs
Outputs of similar age
#57,233
of 259,451 outputs
Outputs of similar age from Nutrition & Metabolism
#7
of 20 outputs
Altmetric has tracked 11,437,561 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 595 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.7. This one has gotten more attention than average, scoring higher than 63% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 259,451 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 77% of its contemporaries.
We're also able to compare this research output to 20 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.