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Malaria parasite clearance

Overview of attention for article published in Malaria Journal, February 2017
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (80th percentile)

Mentioned by

twitter
11 tweeters
patent
1 patent
facebook
1 Facebook page

Citations

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110 Dimensions

Readers on

mendeley
398 Mendeley
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Title
Malaria parasite clearance
Published in
Malaria Journal, February 2017
DOI 10.1186/s12936-017-1731-1
Pubmed ID
Authors

Nicholas J. White

Abstract

Following anti-malarial drug treatment asexual malaria parasite killing and clearance appear to be first order processes. Damaged malaria parasites in circulating erythrocytes are removed from the circulation mainly by the spleen. Splenic clearance functions increase markedly in acute malaria. Either the entire infected erythrocytes are removed because of their reduced deformability or increased antibody binding or, for the artemisinins which act on young ring stage parasites, splenic pitting of drug-damaged parasites is an important mechanism of clearance. The once-infected erythrocytes returned to the circulation have shortened survival. This contributes to post-artesunate haemolysis that may follow recovery in non-immune hyperparasitaemic patients. As the parasites mature Plasmodium vivax-infected erythrocytes become more deformable, whereas Plasmodium falciparum-infected erythrocytes become less deformable, but they escape splenic filtration by sequestering in venules and capillaries. Sequestered parasites are killed in situ by anti-malarial drugs and then disintegrate to be cleared by phagocytic leukocytes. After treatment with artemisinin derivatives some asexual parasites become temporarily dormant within their infected erythrocytes, and these may regrow after anti-malarial drug concentrations decline. Artemisinin resistance in P. falciparum reflects reduced ring stage susceptibility and manifests as slow parasite clearance. This is best assessed from the slope of the log-linear phase of parasitaemia reduction and is commonly measured as a parasite clearance half-life. Pharmacokinetic-pharmacodynamic modelling of anti-malarial drug effects on parasite clearance has proved useful in predicting therapeutic responses and in dose-optimization.

Twitter Demographics

The data shown below were collected from the profiles of 11 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 398 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 <1%
United States 1 <1%
Denmark 1 <1%
Unknown 395 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 72 18%
Student > Ph. D. Student 60 15%
Researcher 58 15%
Student > Bachelor 47 12%
Student > Doctoral Student 23 6%
Other 48 12%
Unknown 90 23%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 65 16%
Agricultural and Biological Sciences 56 14%
Medicine and Dentistry 52 13%
Immunology and Microbiology 37 9%
Pharmacology, Toxicology and Pharmaceutical Science 20 5%
Other 61 15%
Unknown 107 27%

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 July 2022.
All research outputs
#2,998,012
of 22,418,154 outputs
Outputs from Malaria Journal
#722
of 5,474 outputs
Outputs of similar age
#53,811
of 279,587 outputs
Outputs of similar age from Malaria Journal
#1
of 1 outputs
Altmetric has tracked 22,418,154 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,474 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.7. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 279,587 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them