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Epilepsy: neuroinflammation, neurodegeneration, and APOE genotype

Overview of attention for article published in Acta Neuropathologica Communications, July 2013
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Mentioned by

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1 tweeter

Citations

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22 Dimensions

Readers on

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71 Mendeley
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Title
Epilepsy: neuroinflammation, neurodegeneration, and APOE genotype
Published in
Acta Neuropathologica Communications, July 2013
DOI 10.1186/2051-5960-1-41
Pubmed ID
Authors

Orwa Aboud, Robert E Mrak, Frederick A Boop, W Sue T Griffin

Abstract

Precocious development of Alzheimer-type neuropathological changes in epilepsy patients, especially in APOE ϵ4,4 carriers is well known, but not the ways in which other APOE allelic combinations influence this outcome. Frozen and paraffin-embedded tissue samples resected from superior temporal lobes of 92 patients undergoing temporal lobectomies as a treatment for medication-resistant temporal lobe epilepsy were used in this study. To determine if epilepsy-related changes reflect those in another neurological condition, analogous tissue samples harvested from 10 autopsy-verified Alzheimer brains, and from 10 neurologically and neuropathologically normal control patients were analyzed using immunofluorescence histochemistry, western immunoblot, and real-time PCR to determine genotype effects on neuronal number and size, neuronal and glial expressions of amyloid β (Aβ) precursor protein (βAPP), Aβ, apolipoprotein E (ApoE), S100B, interleukin-1α and β, and α and β secretases; and on markers of neuronal stress, including DNA/RNA damage and caspase 3 expression.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 71 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 1%
Spain 1 1%
Ethiopia 1 1%
Unknown 68 96%

Demographic breakdown

Readers by professional status Count As %
Student > Master 16 23%
Researcher 13 18%
Student > Bachelor 9 13%
Student > Doctoral Student 6 8%
Professor > Associate Professor 5 7%
Other 12 17%
Unknown 10 14%
Readers by discipline Count As %
Medicine and Dentistry 18 25%
Neuroscience 15 21%
Agricultural and Biological Sciences 9 13%
Biochemistry, Genetics and Molecular Biology 4 6%
Psychology 4 6%
Other 8 11%
Unknown 13 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 August 2013.
All research outputs
#4,607,640
of 6,231,511 outputs
Outputs from Acta Neuropathologica Communications
#235
of 309 outputs
Outputs of similar age
#67,788
of 100,598 outputs
Outputs of similar age from Acta Neuropathologica Communications
#4
of 6 outputs
Altmetric has tracked 6,231,511 research outputs across all sources so far. This one is in the 15th percentile – i.e., 15% of other outputs scored the same or lower than it.
So far Altmetric has tracked 309 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.3. This one is in the 9th percentile – i.e., 9% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 100,598 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.