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Epilepsy: neuroinflammation, neurodegeneration, and APOE genotype

Overview of attention for article published in Acta Neuropathologica Communications, July 2013
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1 tweeter

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Title
Epilepsy: neuroinflammation, neurodegeneration, and APOE genotype
Published in
Acta Neuropathologica Communications, July 2013
DOI 10.1186/2051-5960-1-41
Pubmed ID
Authors

Orwa Aboud, Robert E Mrak, Frederick A Boop, W Sue T Griffin

Abstract

Precocious development of Alzheimer-type neuropathological changes in epilepsy patients, especially in APOE ϵ4,4 carriers is well known, but not the ways in which other APOE allelic combinations influence this outcome. Frozen and paraffin-embedded tissue samples resected from superior temporal lobes of 92 patients undergoing temporal lobectomies as a treatment for medication-resistant temporal lobe epilepsy were used in this study. To determine if epilepsy-related changes reflect those in another neurological condition, analogous tissue samples harvested from 10 autopsy-verified Alzheimer brains, and from 10 neurologically and neuropathologically normal control patients were analyzed using immunofluorescence histochemistry, western immunoblot, and real-time PCR to determine genotype effects on neuronal number and size, neuronal and glial expressions of amyloid β (Aβ) precursor protein (βAPP), Aβ, apolipoprotein E (ApoE), S100B, interleukin-1α and β, and α and β secretases; and on markers of neuronal stress, including DNA/RNA damage and caspase 3 expression.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 84 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 1%
Spain 1 1%
Ethiopia 1 1%
Unknown 81 96%

Demographic breakdown

Readers by professional status Count As %
Student > Master 16 19%
Researcher 14 17%
Unspecified 9 11%
Student > Bachelor 8 10%
Student > Doctoral Student 7 8%
Other 18 21%
Unknown 12 14%
Readers by discipline Count As %
Medicine and Dentistry 19 23%
Neuroscience 16 19%
Unspecified 10 12%
Agricultural and Biological Sciences 9 11%
Biochemistry, Genetics and Molecular Biology 5 6%
Other 10 12%
Unknown 15 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 August 2013.
All research outputs
#18,342,133
of 22,715,151 outputs
Outputs from Acta Neuropathologica Communications
#1,225
of 1,366 outputs
Outputs of similar age
#148,384
of 198,040 outputs
Outputs of similar age from Acta Neuropathologica Communications
#14
of 23 outputs
Altmetric has tracked 22,715,151 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,366 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.6. This one is in the 5th percentile – i.e., 5% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 198,040 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 23 others from the same source and published within six weeks on either side of this one. This one is in the 4th percentile – i.e., 4% of its contemporaries scored the same or lower than it.