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In vitro evaluation of defined oligosaccharide fractions in an equine model of inflammation

Overview of attention for article published in BMC Veterinary Research, July 2013
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Title
In vitro evaluation of defined oligosaccharide fractions in an equine model of inflammation
Published in
BMC Veterinary Research, July 2013
DOI 10.1186/1746-6148-9-147
Pubmed ID
Abstract

Dietary supplementation with oligosaccharides has been proven to be beneficial for health in several mammalian species. Next to prebiotic effects resulting in a modulation of gut micro biota, immunomodulatory effects of oligosaccharides have been documented in vivo. Supplementation with defined oligosaccharide fractions has been shown to attenuate allergic responses and enhance defensive immune responses. Despite the accumulating evidence for immunomodulatory effects, very limited information is available regarding the direct mechanism of action of oligosaccharides. This study aims to elucidate the effects of selected oligosaccharide fractions on the lipopolysaccharide (LPS) induced inflammatory response in equine peripheral blood mononuclear cells (PBMCs). We investigated three different products containing either galacto-oligosaccharides (GOS) alone, a combination of GOS with fructo-oligosaccharides (FOS), and a triple combination of GOS and FOS with acidic oligosaccharides (AOS), at different concentrations. These products have been used in an identical composition in various previously published in vivo experiments. As the selected oligosaccharide fractions were derived from natural products, the fractions contained defined amounts of mono- and disaccharides and minor amounts of endotoxin, which was taken into account in the design of the study and the analysis of data. Acquired data were analysed in a Bayesian hierarchical linear regression model, accounting for variation between horses.

Mendeley readers

The data shown below were compiled from readership statistics for 40 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 40 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 20%
Student > Ph. D. Student 7 18%
Student > Postgraduate 4 10%
Student > Master 4 10%
Student > Bachelor 3 8%
Other 8 20%
Unknown 6 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 10 25%
Veterinary Science and Veterinary Medicine 7 18%
Medicine and Dentistry 5 13%
Immunology and Microbiology 4 10%
Computer Science 1 3%
Other 2 5%
Unknown 11 28%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 August 2013.
All research outputs
#2,899,503
of 3,630,565 outputs
Outputs from BMC Veterinary Research
#498
of 609 outputs
Outputs of similar age
#67,960
of 85,567 outputs
Outputs of similar age from BMC Veterinary Research
#32
of 36 outputs
Altmetric has tracked 3,630,565 research outputs across all sources so far. This one is in the 2nd percentile – i.e., 2% of other outputs scored the same or lower than it.
So far Altmetric has tracked 609 research outputs from this source. They receive a mean Attention Score of 2.2. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 36 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.