Title |
XIST-induced silencing of flanking genes is achieved by additive action of repeat a monomers in human somatic cells
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Published in |
Epigenetics & Chromatin, August 2013
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DOI | 10.1186/1756-8935-6-23 |
Pubmed ID | |
Authors |
Jakub Minks, Sarah EL Baldry, Christine Yang, Allison M Cotton, Carolyn J Brown |
Abstract |
The establishment of facultative heterochromatin by X-chromosome inactivation requires the long non-coding RNA XIST/Xist. However, the molecular mechanism by which the RNA achieves chromosome-wide gene silencing remains unknown. Mouse Xist has been shown to have redundant domains for cis-localization, and requires a series of well-conserved tandem 'A' repeats for silencing. We previously described a human inducible XIST transgene that is capable of cis-localization and suppressing a downstream reporter gene in somatic cells, and have now leveraged these cells to dissect the sequences critical for XIST-dependent gene silencing in humans. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Argentina | 1 | 33% |
United States | 1 | 33% |
United Kingdom | 1 | 33% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 33% |
Scientists | 1 | 33% |
Science communicators (journalists, bloggers, editors) | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 2% |
Unknown | 62 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 16 | 25% |
Researcher | 12 | 19% |
Student > Master | 12 | 19% |
Student > Bachelor | 5 | 8% |
Student > Doctoral Student | 3 | 5% |
Other | 8 | 13% |
Unknown | 7 | 11% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 28 | 44% |
Biochemistry, Genetics and Molecular Biology | 21 | 33% |
Medicine and Dentistry | 5 | 8% |
Immunology and Microbiology | 1 | 2% |
Unknown | 8 | 13% |