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XIST-induced silencing of flanking genes is achieved by additive action of repeat a monomers in human somatic cells

Overview of attention for article published in Epigenetics & Chromatin, August 2013
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (88th percentile)
  • Good Attention Score compared to outputs of the same age and source (77th percentile)

Mentioned by

blogs
1 blog
twitter
3 X users
patent
1 patent

Citations

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35 Dimensions

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63 Mendeley
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Title
XIST-induced silencing of flanking genes is achieved by additive action of repeat a monomers in human somatic cells
Published in
Epigenetics & Chromatin, August 2013
DOI 10.1186/1756-8935-6-23
Pubmed ID
Authors

Jakub Minks, Sarah EL Baldry, Christine Yang, Allison M Cotton, Carolyn J Brown

Abstract

The establishment of facultative heterochromatin by X-chromosome inactivation requires the long non-coding RNA XIST/Xist. However, the molecular mechanism by which the RNA achieves chromosome-wide gene silencing remains unknown. Mouse Xist has been shown to have redundant domains for cis-localization, and requires a series of well-conserved tandem 'A' repeats for silencing. We previously described a human inducible XIST transgene that is capable of cis-localization and suppressing a downstream reporter gene in somatic cells, and have now leveraged these cells to dissect the sequences critical for XIST-dependent gene silencing in humans.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 63 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Unknown 62 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 16 25%
Researcher 12 19%
Student > Master 12 19%
Student > Bachelor 5 8%
Student > Doctoral Student 3 5%
Other 8 13%
Unknown 7 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 28 44%
Biochemistry, Genetics and Molecular Biology 21 33%
Medicine and Dentistry 5 8%
Immunology and Microbiology 1 2%
Unknown 8 13%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 July 2023.
All research outputs
#2,654,181
of 24,535,155 outputs
Outputs from Epigenetics & Chromatin
#78
of 595 outputs
Outputs of similar age
#22,452
of 203,610 outputs
Outputs of similar age from Epigenetics & Chromatin
#3
of 9 outputs
Altmetric has tracked 24,535,155 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 595 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.6. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 203,610 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 6 of them.