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Expression of SV2 isoforms during rodent brain development

Overview of attention for article published in BMC Neuroscience, August 2013
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Title
Expression of SV2 isoforms during rodent brain development
Published in
BMC Neuroscience, August 2013
DOI 10.1186/1471-2202-14-87
Pubmed ID
Authors

Julie Crèvecœur, Patrik Foerch, Melissa Doupagne, Caroline Thielen, Catherine Vandenplas, Gustave Moonen, Manuel Deprez, Bernard Rogister

Abstract

SV2A, SV2B and SV2C are synaptic vesicle proteins that are structurally related to members of the major facilitator superfamily (MFS). The function and transported substrate of the SV2 proteins is not clearly defined although they are linked to neurotransmitters release in a presynaptic calcium concentration-dependent manner. SV2A and SV2B exhibit broad expression in the central nervous system while SV2C appears to be more restricted in defined areas such as striatum. SV2A knockout mice start to display generalized seizures at a late developmental stage, around post-natal day 7 (P7), and die around P15. More recently, SV2A was demonstrated to be the molecular target of levetiracetam, an approved anti-epileptic drug (AED). The purpose of this work was to precisely analyze and quantify the SV2A, SV2B and SV2C expression during brain development to understand the contribution of these proteins in brain development and their impact on epileptic seizures.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 70 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 1%
Belgium 1 1%
Unknown 68 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 14 20%
Student > Ph. D. Student 12 17%
Student > Master 11 16%
Professor 6 9%
Professor > Associate Professor 6 9%
Other 12 17%
Unknown 9 13%
Readers by discipline Count As %
Neuroscience 20 29%
Agricultural and Biological Sciences 14 20%
Medicine and Dentistry 8 11%
Biochemistry, Genetics and Molecular Biology 3 4%
Psychology 3 4%
Other 8 11%
Unknown 14 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 August 2013.
All research outputs
#3,488,564
of 4,505,915 outputs
Outputs from BMC Neuroscience
#508
of 640 outputs
Outputs of similar age
#72,019
of 90,720 outputs
Outputs of similar age from BMC Neuroscience
#39
of 41 outputs
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So far Altmetric has tracked 640 research outputs from this source. They receive a mean Attention Score of 3.0. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 41 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.