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Restored vision in a young dog following corticosteroid treatment of presumptive hypophysitis

Overview of attention for article published in BMC Veterinary Research, February 2017
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (51st percentile)
  • High Attention Score compared to outputs of the same age and source (90th percentile)

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3 tweeters
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2 Facebook pages

Citations

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5 Dimensions

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55 Mendeley
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Title
Restored vision in a young dog following corticosteroid treatment of presumptive hypophysitis
Published in
BMC Veterinary Research, February 2017
DOI 10.1186/s12917-017-0983-x
Pubmed ID
Authors

Nina Marie Rzechorzek, Tiziana Liuti, Catherine Stalin, Katia Marioni-Henry

Abstract

Hypophysitis is an umbrella term for a group of disorders involving inflammation of the pituitary gland. A rare occurrence in humans, hypophysitis can produce a range of clinical signs including (but not limited to) visual deficits and diabetes insipidus. Only five cases of canine hypophysitis exist in the literature, all presenting in mature dogs with no visual deficits and a grave outcome. This case report describes the clinical and advanced imaging features of blindness-inducing presumptive hypophysitis in a dog, which rapidly resolved with medical management. A 1-year-and-seven-month-old neutered male Standard Poodle presented with subacute blindness, ataxia, and polyuria/polydipsia (PUPD). Magnetic resonance imaging (MRI) detected a contrast-enhancing pituitary mass with perilesional oedema compromising the optic chiasm. Suspecting neoplasia, anti-inflammatory corticosteroid was commenced prior to radiation therapy planning. Complete resolution of neurological and visual deficits occurred within 12 days of starting steroid treatment. Repeated advanced imaging indicated macroscopic resolution of the lesion. An extended thyroid panel with insulin-like growth factor-1 analysis supported a diagnosis of hypophysitis. Resolution of PUPD was achieved with tapering courses of prednisolone and desmopressin; the dog has since been clinically normal for 14 months and treatment-free for 11 months. To the authors' knowledge, this is the first instance in which a canine pituitary mass has demonstrated long-term resolution with palliative medical treatment alone, alongside reversal of associated blindness and presumptive diabetes insipidus. We suspect this lesion to be a form of hypophysitis, which should be included among differential diagnoses for pituitary masses, and for subacute blindness in dogs. Where possible, we advocate biopsy-confirmation of hypophysitis prior to timely intervention with anti-inflammatory treatment.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 55 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 55 100%

Demographic breakdown

Readers by professional status Count As %
Other 12 22%
Student > Postgraduate 6 11%
Student > Doctoral Student 6 11%
Student > Master 5 9%
Student > Bachelor 5 9%
Other 12 22%
Unknown 9 16%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 31 56%
Medicine and Dentistry 7 13%
Neuroscience 3 5%
Nursing and Health Professions 2 4%
Biochemistry, Genetics and Molecular Biology 1 2%
Other 1 2%
Unknown 10 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 April 2017.
All research outputs
#9,245,667
of 16,697,177 outputs
Outputs from BMC Veterinary Research
#723
of 2,459 outputs
Outputs of similar age
#123,847
of 264,424 outputs
Outputs of similar age from BMC Veterinary Research
#3
of 22 outputs
Altmetric has tracked 16,697,177 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,459 research outputs from this source. They receive a mean Attention Score of 3.1. This one has gotten more attention than average, scoring higher than 68% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,424 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.
We're also able to compare this research output to 22 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.