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Hinokitiol induces DNA demethylation via DNMT1 and UHRF1 inhibition in colon cancer cells

Overview of attention for article published in BMC Cell Biology, February 2017
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#15 of 296)
  • Good Attention Score compared to outputs of the same age (78th percentile)

Mentioned by

blogs
1 blog
twitter
2 tweeters

Citations

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30 Dimensions

Readers on

mendeley
22 Mendeley
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Title
Hinokitiol induces DNA demethylation via DNMT1 and UHRF1 inhibition in colon cancer cells
Published in
BMC Cell Biology, February 2017
DOI 10.1186/s12860-017-0130-3
Pubmed ID
Authors

Jung Seon Seo, Young Ha Choi, Ji Wook Moon, Hyeon Soo Kim, Sun-Hwa Park

Abstract

DNA hypermethylation is a key epigenetic mechanism for the silencing of many genes in cancer. Hinokitiol, a tropolone-related natural compound, is known to induce apoptosis and cell cycle arrest and has anti-inflammatory and anti-tumor activities. However, the relationship between hinokitiol and DNA methylation is not clear. The aim of our study was to explore whether hinokitiol has an inhibitory ability on the DNA methylation in colon cancer cells. MTT data showed that hinokitiol had higher sensitivity in colon cancer cells, HCT-116 and SW480, than in normal colon cells, CCD18Co. Hinokitiol reduced DNA methyltransferase 1 (DNMT1) and ubiquitin-like plant homeodomain and RING finger domain 1 (UHRF1) expression in HCT-116 cells. In addition, the expression of ten-eleven translocation protein 1 (TET1), a known DNA demethylation initiator, was increased by hinokitiol treatment. ELISA and FACS data showed that hinokitiol increased the 5-hydroxymethylcytosine (5hmC) level in the both colon cancer cells, but 5-methylcytosine (5mC) level was not changed. Furthermore, hinokitiol significantly restored mRNA expression of O(6)-methylguanine DNA methyltransferase (MGMT), carbohydrate sulfotransferase 10 (CHST10), and B-cell translocation gene 4 (BTG4) concomitant with reduction of methylation status in HCT-116 cells. These results indicate that hinokitiol may exert DNA demethylation by inhibiting the expression of DNMT1 and UHRF1 in colon cancer cells.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 22 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 32%
Student > Master 4 18%
Student > Postgraduate 2 9%
Student > Bachelor 2 9%
Unspecified 1 5%
Other 2 9%
Unknown 4 18%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 8 36%
Medicine and Dentistry 4 18%
Agricultural and Biological Sciences 3 14%
Psychology 1 5%
Unspecified 1 5%
Other 0 0%
Unknown 5 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 March 2017.
All research outputs
#2,497,763
of 15,920,152 outputs
Outputs from BMC Cell Biology
#15
of 296 outputs
Outputs of similar age
#57,304
of 263,048 outputs
Outputs of similar age from BMC Cell Biology
#1
of 1 outputs
Altmetric has tracked 15,920,152 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 296 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 263,048 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 78% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them