Title |
Efficacy of prosultiamine treatment in patients with human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis: results from an open-label clinical trial
|
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Published in |
BMC Medicine, August 2013
|
DOI | 10.1186/1741-7015-11-182 |
Pubmed ID | |
Authors |
Tatsufumi Nakamura, Tomohiro Matsuo, Taku Fukuda, Shinji Yamato, Kentaro Yamaguchi, Ikuo Kinoshita, Toshio Matsuzaki, Yoshihiro Nishiura, Kunihiko Nagasato, Tomoko Narita-Masuda, Hideki Nakamura, Katsuya Satoh, Hitoshi Sasaki, Hideki Sakai, Atsushi Kawakami |
Abstract |
Human T lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a chronic myelopathy characterized by motor dysfunction of the lower extremities and urinary disturbance. Immunomodulatory treatments are the main strategy for HAM/TSP, but several issues are associated with long-term treatment. We conducted a clinical trial with prosultiamine (which has apoptotic activity against HTLV-I-infected cells) as a novel therapy in HAM/TSP patients. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 17% |
United Kingdom | 1 | 17% |
Unknown | 4 | 67% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 67% |
Science communicators (journalists, bloggers, editors) | 1 | 17% |
Practitioners (doctors, other healthcare professionals) | 1 | 17% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Brazil | 2 | 3% |
Colombia | 1 | 2% |
Unknown | 59 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 11 | 18% |
Student > Master | 11 | 18% |
Student > Doctoral Student | 8 | 13% |
Student > Bachelor | 8 | 13% |
Researcher | 6 | 10% |
Other | 12 | 19% |
Unknown | 6 | 10% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 24 | 39% |
Nursing and Health Professions | 7 | 11% |
Agricultural and Biological Sciences | 7 | 11% |
Sports and Recreations | 3 | 5% |
Immunology and Microbiology | 3 | 5% |
Other | 9 | 15% |
Unknown | 9 | 15% |