Title |
A cohort study of Chlamydia trachomatis treatment failure in women: a study protocol
|
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Published in |
BMC Infectious Diseases, August 2013
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DOI | 10.1186/1471-2334-13-379 |
Pubmed ID | |
Authors |
Jane S Hocking, Lenka A Vodstrcil, Wilhelmina M Huston, Peter Timms, Marcus Y Chen, Karen Worthington, Ruthy McIver, Sepehr N Tabrizi |
Abstract |
Chlamydia trachomatis is the most commonly diagnosed bacterial sexually transmitted infection in the developed world and diagnosis rates have increased dramatically over the last decade. Repeat infections of chlamydia are very common and may represent re-infection from an untreated partner or treatment failure. The aim of this cohort study is to estimate the proportion of women infected with chlamydia who experience treatment failure after treatment with 1 gram azithromycin.Methods/design: This cohort study will follow women diagnosed with chlamydia for up to 56 days post treatment. Women will provide weekly genital specimens for further assay. The primary outcome is the proportion of women who are classified as having treatment failure 28, 42 or 56 days after recruitment. Comprehensive sexual behavior data collection and the detection of Y chromosome DNA and high discriminatory chlamydial genotyping will be used to differentiate between chlamydia re-infection and treatment failure. Azithromycin levels in high-vaginal specimens will be measured using a validated liquid chromatography -- tandem mass spectrometry method to assess whether poor azithromycin absorption could be a cause of treatment failure. Chlamydia culture and minimal inhibitory concentrations will be performed to further characterize the chlamydia infections. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Denmark | 1 | 2% |
Unknown | 49 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 6 | 12% |
Student > Doctoral Student | 6 | 12% |
Student > Bachelor | 6 | 12% |
Student > Postgraduate | 5 | 10% |
Student > Ph. D. Student | 5 | 10% |
Other | 13 | 26% |
Unknown | 9 | 18% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 12 | 24% |
Nursing and Health Professions | 7 | 14% |
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 12% |
Agricultural and Biological Sciences | 5 | 10% |
Biochemistry, Genetics and Molecular Biology | 3 | 6% |
Other | 6 | 12% |
Unknown | 11 | 22% |