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A cohort study of Chlamydia trachomatis treatment failure in women: a study protocol

Overview of attention for article published in BMC Infectious Diseases, August 2013
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Title
A cohort study of Chlamydia trachomatis treatment failure in women: a study protocol
Published in
BMC Infectious Diseases, August 2013
DOI 10.1186/1471-2334-13-379
Pubmed ID
Authors

Jane S Hocking, Lenka A Vodstrcil, Wilhelmina M Huston, Peter Timms, Marcus Y Chen, Karen Worthington, Ruthy McIver, Sepehr N Tabrizi

Abstract

Chlamydia trachomatis is the most commonly diagnosed bacterial sexually transmitted infection in the developed world and diagnosis rates have increased dramatically over the last decade. Repeat infections of chlamydia are very common and may represent re-infection from an untreated partner or treatment failure. The aim of this cohort study is to estimate the proportion of women infected with chlamydia who experience treatment failure after treatment with 1 gram azithromycin.Methods/design: This cohort study will follow women diagnosed with chlamydia for up to 56 days post treatment. Women will provide weekly genital specimens for further assay. The primary outcome is the proportion of women who are classified as having treatment failure 28, 42 or 56 days after recruitment. Comprehensive sexual behavior data collection and the detection of Y chromosome DNA and high discriminatory chlamydial genotyping will be used to differentiate between chlamydia re-infection and treatment failure. Azithromycin levels in high-vaginal specimens will be measured using a validated liquid chromatography -- tandem mass spectrometry method to assess whether poor azithromycin absorption could be a cause of treatment failure. Chlamydia culture and minimal inhibitory concentrations will be performed to further characterize the chlamydia infections.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 50 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Denmark 1 2%
Unknown 49 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 6 12%
Student > Doctoral Student 6 12%
Student > Bachelor 6 12%
Student > Postgraduate 5 10%
Student > Ph. D. Student 5 10%
Other 13 26%
Unknown 9 18%
Readers by discipline Count As %
Medicine and Dentistry 12 24%
Nursing and Health Professions 7 14%
Pharmacology, Toxicology and Pharmaceutical Science 6 12%
Agricultural and Biological Sciences 5 10%
Biochemistry, Genetics and Molecular Biology 3 6%
Other 6 12%
Unknown 11 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 September 2013.
All research outputs
#18,819,234
of 23,322,258 outputs
Outputs from BMC Infectious Diseases
#5,712
of 7,806 outputs
Outputs of similar age
#150,030
of 200,148 outputs
Outputs of similar age from BMC Infectious Diseases
#95
of 145 outputs
Altmetric has tracked 23,322,258 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,806 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.3. This one is in the 15th percentile – i.e., 15% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 200,148 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 145 others from the same source and published within six weeks on either side of this one. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.