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Petiveria alliacea extracts uses multiple mechanisms to inhibit growth of human and mouse tumoral cells

Overview of attention for article published in BMC Complementary and Alternative Medicine, November 2008
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (90th percentile)

Mentioned by

news
1 news outlet
twitter
3 tweeters
patent
1 patent
video
1 video uploader

Citations

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33 Dimensions

Readers on

mendeley
70 Mendeley
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Title
Petiveria alliacea extracts uses multiple mechanisms to inhibit growth of human and mouse tumoral cells
Published in
BMC Complementary and Alternative Medicine, November 2008
DOI 10.1186/1472-6882-8-60
Pubmed ID
Authors

Claudia Urueña, Claudia Cifuentes, Diana Castañeda, Amparo Arango, Punit Kaur, Alexzander Asea, Susana Fiorentino

Abstract

There is ethnopharmacological evidence that Petiveria alliacea can have antitumor activity; however, the mechanism of its cytotoxic activity is not well understood. We assessed multiple in vitro biological activities of an ethyl acetate soluble plant fraction over several tumor cell lines. Tumor cell lines were evaluated using the following tests: trypan blue exclusion test, MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide], flow cytometry, cytoskeleton organization analysis, cell cycle, mitochondria membrane depolarization, clonogenicity test, DNA fragmentation test and differential protein expression by HPLC-Chip/MS analysis. F4 fraction characterization was made by HPLC-MS. Petiveria alliacea fraction characterized by de-replication was found to alter actin cytoskeleton organization, induce G2 cell cycle arrest and cause apoptotic cell death in a mitochondria independent way. In addition, we found down regulation of cytoskeleton, chaperone, signal transduction proteins, and proteins involved in metabolic pathways. Finally up regulation of proteins involved in translation and intracellular degradation was also observed. The results of this study indicate that Petiveria alliacea exerts multiple biological activities in vitro consistent with cytotoxicity. Further studies in animal models are needed but Petiveria alliacea appears to be a good candidate to be used as an antitumor agent.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 70 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Indonesia 1 1%
India 1 1%
Unknown 68 97%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 12 17%
Student > Ph. D. Student 11 16%
Researcher 8 11%
Student > Doctoral Student 8 11%
Student > Postgraduate 5 7%
Other 15 21%
Unknown 11 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 21 30%
Chemistry 10 14%
Pharmacology, Toxicology and Pharmaceutical Science 7 10%
Biochemistry, Genetics and Molecular Biology 7 10%
Medicine and Dentistry 6 9%
Other 11 16%
Unknown 8 11%

Attention Score in Context

This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 July 2019.
All research outputs
#1,267,212
of 15,355,386 outputs
Outputs from BMC Complementary and Alternative Medicine
#252
of 2,963 outputs
Outputs of similar age
#14,897
of 161,829 outputs
Outputs of similar age from BMC Complementary and Alternative Medicine
#1
of 1 outputs
Altmetric has tracked 15,355,386 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,963 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.1. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 161,829 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them