↓ Skip to main content

Berberine improves glucogenesis and lipid metabolism in nonalcoholic fatty liver disease

Overview of attention for article published in BMC Endocrine Disorders, February 2017
Altmetric Badge

About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (72nd percentile)
  • Good Attention Score compared to outputs of the same age and source (71st percentile)

Mentioned by

twitter
10 X users

Citations

dimensions_citation
70 Dimensions

Readers on

mendeley
57 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Berberine improves glucogenesis and lipid metabolism in nonalcoholic fatty liver disease
Published in
BMC Endocrine Disorders, February 2017
DOI 10.1186/s12902-017-0165-7
Pubmed ID
Authors

Li Zhao, Zhen Cang, Honglin Sun, Xiaomin Nie, Ningjian Wang, Yingli Lu

Abstract

Nonalcoholic fatty liver disease (NAFLD) is considered a critical hepatic manifestation of metabolic syndrome. Berberine (BBR) exerts anti-hyperglycemic and anti-dyslipidemic effects and can also ameliorate NAFLD. Thus, BBR might exert its therapeutic effect on NAFLD by improving glucolipid metabolism. Here, we investigated the aspects and extent to which glucolipid metabolism were affected by BBR in rats with NAFLD. Three groups of Sprague-Dawley rats were studied: a control group (n = 6) fed a normal chow diet and a NAFLD group (n = 6) and a NAFLD + BBR group (n = 6) fed a high-fat diet. Normal saline and BBR (150 mg/kg body weight/day for 16 weeks) were administered by gavage. All rats were infused with isotope tracers. The rates of glucose appearance (Raglu), gluconeogenesis (GNG) and glycerol appearance (Ragly) were assessed with (2)H and (13)C tracers, whereas the rates of hepatic lipogenesis and fatty acid β oxidation were measured using the (3)H tracer. When the NAFLD model was successfully induced by administering a high-fat diet, body weight, insulin resistance and dyslipidemia were significantly increased. After the BBR treatment, weight loss, decreased lipid profiles and HOMA-IR, and increased ISI were observed. Meanwhile, BBR reduced Raglu, GNG and hepatic lipogenesis, whereas the rate of fatty acid β oxidation in skeletal muscle showed an increasing trend. Ragly showed a decreasing trend. Based on the results of the histological analysis, BBR obviously attenuated the ectopic liver fat accumulation. BBR improved NAFLD by inhibiting glucogenesis and comprehensively regulating lipid metabolism, and its effect on inhibiting hepatic lipogenesis was much stronger. The improvement may be partly mediated by weight loss. Berberine might be a good choice for patients with NAFLD and glucose metabolic disorder. Future clinical trials need to be conducted to confirm these effects.

X Demographics

X Demographics

The data shown below were collected from the profiles of 10 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 57 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 1 2%
Unknown 56 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 14%
Student > Bachelor 8 14%
Student > Ph. D. Student 6 11%
Other 4 7%
Student > Doctoral Student 3 5%
Other 9 16%
Unknown 19 33%
Readers by discipline Count As %
Medicine and Dentistry 11 19%
Pharmacology, Toxicology and Pharmaceutical Science 7 12%
Biochemistry, Genetics and Molecular Biology 4 7%
Nursing and Health Professions 3 5%
Neuroscience 3 5%
Other 4 7%
Unknown 25 44%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 March 2017.
All research outputs
#5,126,037
of 24,417,958 outputs
Outputs from BMC Endocrine Disorders
#195
of 822 outputs
Outputs of similar age
#86,417
of 315,007 outputs
Outputs of similar age from BMC Endocrine Disorders
#5
of 14 outputs
Altmetric has tracked 24,417,958 research outputs across all sources so far. Compared to these this one has done well and is in the 78th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 822 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.2. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 315,007 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.