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Mendeley readers
Attention Score in Context
| Title |
The underlying mechanism of prodromal PD: insights from the parasympathetic nervous system and the olfactory system
|
|---|---|
| Published in |
Translational Neurodegeneration, February 2017
|
| DOI | 10.1186/s40035-017-0074-8 |
| Pubmed ID | |
| Authors |
Shu-Ying Liu, Piu Chan, A. Jon Stoessl |
| Abstract |
Neurodegeneration of Parkinson's disease (PD) starts in an insidious manner, 30-50% of dopaminergic neurons have been lost in the substantia nigra before clinical diagnosis. Prodromal stage of the disease, during which the disease pathology has started but is insufficient to result in clinical manifestations, offers a valuable window for disease-modifying therapies. The most focused underlying mechanisms linking the pathological pattern and clinical characteristics of prodromal PD are the prion hypothesis of alpha-synuclein and the selective vulnerability of neurons. In this review, we consider the two potential portals, the vagus nerve and the olfactory bulb, through which abnormal alpha-synuclein can access the brain. We review the clinical, pathological and neuroimaging evidence of the parasympathetic nervous system and the olfactory system in the neurodegenerative process and using the two systems as models to discuss the internal homogeneity and heterogeneity of the prodromal stage of PD, including both the clustering and subtyping of symptoms and signs. Finally, we offer some suggestions on future directions for imaging studies in prodromal Parkinson's disease. |
Mendeley readers
The data shown below were compiled from readership statistics for 59 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 59 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 8 | 14% |
| Student > Master | 7 | 12% |
| Student > Bachelor | 6 | 10% |
| Student > Ph. D. Student | 5 | 8% |
| Student > Doctoral Student | 4 | 7% |
| Other | 11 | 19% |
| Unknown | 18 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 12 | 20% |
| Medicine and Dentistry | 10 | 17% |
| Agricultural and Biological Sciences | 8 | 14% |
| Biochemistry, Genetics and Molecular Biology | 4 | 7% |
| Business, Management and Accounting | 1 | 2% |
| Other | 6 | 10% |
| Unknown | 18 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 March 2017.
All research outputs
#4,837,286
of 25,382,440 outputs
Outputs from Translational Neurodegeneration
#233
of 384 outputs
Outputs of similar age
#80,476
of 323,273 outputs
Outputs of similar age from Translational Neurodegeneration
#4
of 7 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 384 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 29.7. This one is in the 28th percentile – i.e., 28% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 323,273 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.