Title |
Gene-environment and protein-degradation signatures characterize genomic and phenotypic diversity in wild Caenorhabditis eleganspopulations
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Published in |
BMC Biology, August 2013
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DOI | 10.1186/1741-7007-11-93 |
Pubmed ID | |
Authors |
Rita JM Volkers, L Basten Snoek, Caspara J van Hellenberg Hubar, Renata Coopman, Wei Chen, Wentao Yang, Mark G Sterken, Hinrich Schulenburg, Bart P Braeckman, Jan E Kammenga |
Abstract |
Analyzing and understanding the relationship between genotypes and phenotypes is at the heart of genetics. Research on the nematode Caenorhabditis elegans has been instrumental for unraveling genotype-phenotype relations, and has important implications for understanding the biology of mammals, but almost all studies, including forward and reverse genetic screens, are limited by investigations in only one canonical genotype. This hampers the detection and functional analysis of allelic variants, which play a key role in controlling many complex traits. It is therefore essential to explore the full potential of the natural genetic variation and evolutionary context of the genotype-phenotype map in wild C. elegans populations. |
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Demographic breakdown
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Mendeley readers
Geographical breakdown
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Professor > Associate Professor | 6 | 8% |
Student > Master | 6 | 8% |
Other | 10 | 13% |
Unknown | 10 | 13% |
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Pharmacology, Toxicology and Pharmaceutical Science | 1 | 1% |
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