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Metabolic improvements following Roux-en-Y surgery assessed by solid meal test in subjects with short duration type 2 diabetes

Overview of attention for article published in BMC Obesity, March 2017
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Title
Metabolic improvements following Roux-en-Y surgery assessed by solid meal test in subjects with short duration type 2 diabetes
Published in
BMC Obesity, March 2017
DOI 10.1186/s40608-017-0149-1
Pubmed ID
Authors

Sudha S. Shankar, Lori A. Mixson, Manu Chakravarthy, Robin Chisholm, Anthony J. Acton, RoseMarie Jones, Samer G. Mattar, Deborah L. Miller, Lea Petry, Chan R. Beals, S. Aubrey Stoch, David E. Kelley, Robert V. Considine

Abstract

Glucose homeostasis improves within days following Roux-en-Y gastric bypass (RYGB) surgery. The dynamic metabolic response to caloric intake following RYGB has been assessed using liquid mixed meal tolerance tests (MMTT). Few studies have evaluated the glycemic and hormonal response to a solid mixed meal in subjects with diabetes prior to, and within the first month following RYGB. Seventeen women with type 2 diabetes of less than 5 years duration participated. Fasting measures of glucose homeostasis, lipids and gut hormones were obtained pre- and post-surgery. MMTT utilizing a solid 4 oz chocolate pudding performed pre-, 2 and 4 weeks post-surgery. Metabolic response to 4 and 2 oz MMTT assessed in five diabetic subjects not undergoing surgery. Significant reductions in fasting glucose and insulin at 3 days, and in fasting betatrophin, triglycerides and total cholesterol at 2 weeks post-surgery. Hepatic insulin clearance was greater at 3 days post-surgery. Subjects exhibited less hunger and greater feelings of fullness and satisfaction during the MMTT while consuming 52.9 ± 6.5% and 51.0 ± 6.5% of the meal at 2 and 4 weeks post-surgery respectively. At 2 weeks post-surgery, glucose and insulin response to MMTT were improved, with greater GLP-1 and PYY secretion. Improved response to solid MMTT not replicated by consumption of smaller pudding volume in diabetic non-surgical subjects. With a test meal of size and composition representative of the routine diet of post-RYGB subjects, improved glycemic and gut hormone responses occur which cannot be replicated by reducing the size of the MMTT in diabetic subjects not undergoing surgery. Clinical Trials.gov Identifier: NCT00957957 August 11, 2009.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 25 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 16%
Student > Bachelor 4 16%
Student > Master 3 12%
Other 3 12%
Student > Doctoral Student 2 8%
Other 6 24%
Unknown 3 12%
Readers by discipline Count As %
Medicine and Dentistry 9 36%
Biochemistry, Genetics and Molecular Biology 5 20%
Agricultural and Biological Sciences 2 8%
Pharmacology, Toxicology and Pharmaceutical Science 2 8%
Sports and Recreations 1 4%
Other 0 0%
Unknown 6 24%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 March 2017.
All research outputs
#6,969,556
of 9,143,179 outputs
Outputs from BMC Obesity
#111
of 138 outputs
Outputs of similar age
#185,812
of 253,091 outputs
Outputs of similar age from BMC Obesity
#7
of 7 outputs
Altmetric has tracked 9,143,179 research outputs across all sources so far. This one is in the 13th percentile – i.e., 13% of other outputs scored the same or lower than it.
So far Altmetric has tracked 138 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.6. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
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