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Suppression of ovine lymphocyte activation by Teladorsagia circumcincta larval excretory-secretory products.

Overview of attention for article published in Veterinary Research, August 2013
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  • Above-average Attention Score compared to outputs of the same age (56th percentile)
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Title
Suppression of ovine lymphocyte activation by Teladorsagia circumcincta larval excretory-secretory products.
Published in
Veterinary Research, August 2013
DOI 10.1186/1297-9716-44-70
Pubmed ID
Authors

McNeilly TN, Rocchi M, Bartley Y, Brown JK, Frew D, Longhi C, McLean L, McIntyre J, Nisbet AJ, Wattegedera S, Huntley JF, Matthews JB, Tom N McNeilly, Mara Rocchi, Yvonne Bartley, Jeremy K Brown, David Frew, Cassandra Longhi, Louise McLean, Jenni McIntyre, Alasdair J Nisbet, Sean Wattegedera, John F Huntley, Jacqueline B Matthews

Abstract

Teladorsagia circumcincta is an important pathogenic nematode of sheep. It has been demonstrated previously that stimulation of murine T lymphocytes with excretory-secretory (ES) products derived from fourth stage larvae of T. circumcincta (Tci-L4-ES) results in de novo expression of Foxp3, a transcription factor intimately involved in regulatory T cell function. In the current study, Foxp3⁺ T cell responses in the abomasum and the effects of Tci-L4-ES on ovine peripheral blood mononuclear cells (PBMC) following T. circumcincta infection were investigated. T. circumcincta infection resulted in a significant increase in numbers of abomasal Foxp3⁺ T cells, but not an increase in the proportion of T cells expressing Foxp3. Unlike in mice, Tci-L4-ES was incapable of inducing T cell Foxp3 expression but instead suppressed mitogen-induced and antigen-specific activation and proliferation of ovine PBMC in vitro. This effect was heat labile, suggesting that it is mediated by protein(s). Suppression was associated with up-regulation of interleukin-10 (IL-10) mRNA, and specific monoclonal antibody neutralisation of IL-10 resulted in a 50% reduction in suppression, indicating involvement of the IL-10 signaling pathway. Suppression was significantly reduced in PBMC isolated from T. circumcincta infected vs. helminth-naïve lambs, and this reduction in suppression was associated with an increase in Tci-L4-ES antigen-specific T cells within the PBMC. In conclusion, we have identified a mechanism by which T. circumcincta may modulate the host adaptive immune response, potentially assisting survival of the parasite within the host. However, the impact of Tci-L4-ES-mediated lymphocyte suppression during T. circumcincta infection remains to be determined.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 3%
Unknown 31 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 12 38%
Researcher 10 31%
Student > Bachelor 4 13%
Professor 1 3%
Other 1 3%
Other 2 6%
Unknown 2 6%
Readers by discipline Count As %
Agricultural and Biological Sciences 11 34%
Veterinary Science and Veterinary Medicine 5 16%
Medicine and Dentistry 5 16%
Immunology and Microbiology 3 9%
Nursing and Health Professions 1 3%
Other 1 3%
Unknown 6 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 July 2014.
All research outputs
#1,988,908
of 4,507,280 outputs
Outputs from Veterinary Research
#185
of 417 outputs
Outputs of similar age
#38,357
of 93,553 outputs
Outputs of similar age from Veterinary Research
#14
of 31 outputs
Altmetric has tracked 4,507,280 research outputs across all sources so far. This one has received more attention than most of these and is in the 53rd percentile.
So far Altmetric has tracked 417 research outputs from this source. They receive a mean Attention Score of 2.6. This one has gotten more attention than average, scoring higher than 51% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 93,553 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 56% of its contemporaries.
We're also able to compare this research output to 31 others from the same source and published within six weeks on either side of this one. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.