Title |
Anti-inflammatory and immunomodulatory mechanisms of mesenchymal stem cell transplantation in experimental traumatic brain injury
|
---|---|
Published in |
Journal of Neuroinflammation, August 2013
|
DOI | 10.1186/1742-2094-10-106 |
Pubmed ID | |
Authors |
Run Zhang, Yi Liu, Ke Yan, Lei Chen, Xiang-Rong Chen, Peng Li, Fan-Fan Chen, Xiao-Dan Jiang |
Abstract |
Previous studies have shown beneficial effects of mesenchymal stem cell (MSC) transplantation in central nervous system (CNS) injuries, including traumatic brain injury (TBI). Potential repair mechanisms involve transdifferentiation to replace damaged neural cells and production of growth factors by MSCs. However, few studies have simultaneously focused on the effects of MSCs on immune cells and inflammation-associated cytokines in CNS injury, especially in an experimental TBI model. In this study, we investigated the anti-inflammatory and immunomodulatory properties of MSCs in TBI-induced neuroinflammation by systemic transplantation of MSCs into a rat TBI model. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 50% |
United Kingdom | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | <1% |
Germany | 2 | <1% |
Unknown | 201 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 34 | 17% |
Researcher | 34 | 17% |
Student > Master | 26 | 13% |
Student > Bachelor | 25 | 12% |
Student > Doctoral Student | 9 | 4% |
Other | 29 | 14% |
Unknown | 48 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 43 | 21% |
Medicine and Dentistry | 29 | 14% |
Biochemistry, Genetics and Molecular Biology | 28 | 14% |
Neuroscience | 25 | 12% |
Immunology and Microbiology | 9 | 4% |
Other | 18 | 9% |
Unknown | 53 | 26% |