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X Demographics
Mendeley readers
Attention Score in Context
| Title |
A path analysis of multiple neurotoxic chemicals and cognitive functioning in older US adults (NHANES 1999–2002)
|
|---|---|
| Published in |
Environmental Health, March 2017
|
| DOI | 10.1186/s12940-017-0227-3 |
| Pubmed ID | |
| Authors |
Jennifer Przybyla, E. Andres Houseman, Ellen Smit, Molly L. Kile |
| Abstract |
Polychlorinated biphenyls (PCBs) and metals (lead and cadmium) are neurotoxic and affect neurobehavioral performance. Yet little is known about the association between exposure to multiple neurotoxic compounds and cognitive functioning in older adults. Using data from two consecutive cycles of the National Health and Nutrition and Examination Survey (1999-2002), path analysis was used to simultaneously evaluate the association between whole blood concentrations of 14 neurotoxic compounds and cognitive functioning measured by the Digit Symbol Coding Test of the Weschler Adult Intelligence Scale, 3(rd) Edition in participants 60-84 years of age (N = 498). Effect modification was assessed for age (above/below the mean) and sex. The final path model fit 5 compounds (i.e. PCB 74, PCB 118, PCB 146, PCB 153, and lead). After controlling for co-exposures and confounders, PCB 146 (β = -0.16, 95% CI: -0.29, -0.02, p = 0.02) and lead (β = -0.10, 95% CI: -0.20, -0.006, p = 0.04) were negatively associated with DSC scores in 60-84 year olds. Whereas, PCB 153 was positively associated with DSC scores (β =0.20, 95% CI: 0.05, 0.35; p = 0.01). This cross-sectional analysis which controlled for collinear exposure to several neurotoxic compounds demonstrated an association between non-dioxin like polychlorinated biphenyl exposure, specifically PCB 146, and lower cognitive functioning, in older adults. Lead exposure was also weakly associated with lower cognitive functioning. Additional studies are needed to determine the causality of the observed associations. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 39 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 5 | 13% |
| Researcher | 5 | 13% |
| Student > Master | 4 | 10% |
| Other | 3 | 8% |
| Student > Doctoral Student | 3 | 8% |
| Other | 3 | 8% |
| Unknown | 16 | 41% |
| Readers by discipline | Count | As % |
|---|---|---|
| Nursing and Health Professions | 4 | 10% |
| Environmental Science | 3 | 8% |
| Agricultural and Biological Sciences | 3 | 8% |
| Biochemistry, Genetics and Molecular Biology | 2 | 5% |
| Medicine and Dentistry | 2 | 5% |
| Other | 7 | 18% |
| Unknown | 18 | 46% |
Attention Score in Context
This research output has an Altmetric Attention Score of 55. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 May 2017.
All research outputs
#658,446
of 22,958,253 outputs
Outputs from Environmental Health
#161
of 1,498 outputs
Outputs of similar age
#15,306
of 307,998 outputs
Outputs of similar age from Environmental Health
#7
of 37 outputs
Altmetric has tracked 22,958,253 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,498 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 31.3. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 307,998 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 37 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.