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A path analysis of multiple neurotoxic chemicals and cognitive functioning in older US adults (NHANES 1999–2002)

Overview of attention for article published in Environmental Health, March 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (94th percentile)

Mentioned by

news
7 news outlets
twitter
1 tweeter

Citations

dimensions_citation
19 Dimensions

Readers on

mendeley
35 Mendeley
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Title
A path analysis of multiple neurotoxic chemicals and cognitive functioning in older US adults (NHANES 1999–2002)
Published in
Environmental Health, March 2017
DOI 10.1186/s12940-017-0227-3
Pubmed ID
Authors

Jennifer Przybyla, E. Andres Houseman, Ellen Smit, Molly L. Kile

Abstract

Polychlorinated biphenyls (PCBs) and metals (lead and cadmium) are neurotoxic and affect neurobehavioral performance. Yet little is known about the association between exposure to multiple neurotoxic compounds and cognitive functioning in older adults. Using data from two consecutive cycles of the National Health and Nutrition and Examination Survey (1999-2002), path analysis was used to simultaneously evaluate the association between whole blood concentrations of 14 neurotoxic compounds and cognitive functioning measured by the Digit Symbol Coding Test of the Weschler Adult Intelligence Scale, 3(rd) Edition in participants 60-84 years of age (N = 498). Effect modification was assessed for age (above/below the mean) and sex. The final path model fit 5 compounds (i.e. PCB 74, PCB 118, PCB 146, PCB 153, and lead). After controlling for co-exposures and confounders, PCB 146 (β = -0.16, 95% CI: -0.29, -0.02, p = 0.02) and lead (β = -0.10, 95% CI: -0.20, -0.006, p = 0.04) were negatively associated with DSC scores in 60-84 year olds. Whereas, PCB 153 was positively associated with DSC scores (β =0.20, 95% CI: 0.05, 0.35; p = 0.01). This cross-sectional analysis which controlled for collinear exposure to several neurotoxic compounds demonstrated an association between non-dioxin like polychlorinated biphenyl exposure, specifically PCB 146, and lower cognitive functioning, in older adults. Lead exposure was also weakly associated with lower cognitive functioning. Additional studies are needed to determine the causality of the observed associations.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 35 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 6 17%
Student > Bachelor 5 14%
Researcher 5 14%
Student > Doctoral Student 3 9%
Other 2 6%
Other 2 6%
Unknown 12 34%
Readers by discipline Count As %
Nursing and Health Professions 4 11%
Environmental Science 3 9%
Biochemistry, Genetics and Molecular Biology 3 9%
Agricultural and Biological Sciences 3 9%
Psychology 2 6%
Other 6 17%
Unknown 14 40%

Attention Score in Context

This research output has an Altmetric Attention Score of 55. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 May 2017.
All research outputs
#566,595
of 20,568,640 outputs
Outputs from Environmental Health
#146
of 1,415 outputs
Outputs of similar age
#13,932
of 275,284 outputs
Outputs of similar age from Environmental Health
#1
of 1 outputs
Altmetric has tracked 20,568,640 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,415 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 30.0. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 275,284 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them