Title |
Primary cerebral low-grade B-cell lymphoma, monoclonal immunoglobulin deposition disease, cerebral light chain deposition disease and “aggregoma”: an update on classification and diagnosis
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Published in |
BMC Neurology, August 2013
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DOI | 10.1186/1471-2377-13-107 |
Pubmed ID | |
Authors |
Marco Skardelly, Georgios Pantazis, Sotirios Bisdas, Guenther C Feigl, Martin U Schuhmann, Marcos S Tatagiba, Rainer Ritz |
Abstract |
This work aims to add evidence and provide an update on the classification and diagnosis of monoclonal immunoglobulin deposition disease (MIDD) and primary central nervous system low-grade lymphomas. MIDD is characterized by the deposition of light and heavy chain proteins. Depending on the spatial arrangement of the secreted proteins, light chain-derived amyloidosis (AL) can be distinguished from non-amyloid light chain deposition disease (LCDD). We present a case of an extremely rare tumoral presentation of LCDD (aggregoma) and review the 3 previously published LCDD cases and discuss their presentation with respect to AL. |
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