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A novel phenoxy thiophene sulphonamide molecule protects against glutamate evoked oxidative injury in a neuronal cell model

Overview of attention for article published in BMC Neuroscience, September 2013
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1 tweeter

Citations

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30 Mendeley
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Title
A novel phenoxy thiophene sulphonamide molecule protects against glutamate evoked oxidative injury in a neuronal cell model
Published in
BMC Neuroscience, September 2013
DOI 10.1186/1471-2202-14-93
Pubmed ID
Authors

Nailya S Gliyazova, Eun Y Huh, Gordon C Ibeanu

Abstract

Glutamate is one of the major neurotransmitters in the central nervous system. It is a potent neurotoxin capable of neuronal destruction through numerous signal pathways when present in high concentration. Glutamate-evoked excitotoxicity has been implicated in the etiology of many neurodegenerative diseases including Alzheimer's disease (AD), Parkinson's disease (PD), and ischemic stroke. Increasing evidence has shown that reactive oxygen species (ROS) provoked by glutamate-linked oxidative stress plays a crucial role in the pathogenesis of these disorders. We previously reported the discovery of an aryl thiophene compound, 4-chloro-N-(naphthalen-1-ylmethyl)-5-(3-(piperazin-1-yl)phenoxy)thiophene-2-sulfonamide (B355252) from a proprietary library of small molecules. We showed that this compound was capable of potentiating nerve growth factor (NGF)-primed neurite outgrowth in neuronal cell models in a low NGF environment. In the present study we investigated the neuroprotective effects and signaling pathways of B355252 on glutamate-evoked excitotoxicity in HT-22, a murine hippocampal neuronal cell line.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 3%
Unknown 29 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 27%
Student > Ph. D. Student 7 23%
Student > Master 6 20%
Student > Doctoral Student 3 10%
Student > Bachelor 1 3%
Other 4 13%
Unknown 1 3%
Readers by discipline Count As %
Agricultural and Biological Sciences 9 30%
Neuroscience 4 13%
Psychology 3 10%
Medicine and Dentistry 3 10%
Biochemistry, Genetics and Molecular Biology 2 7%
Other 7 23%
Unknown 2 7%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 September 2013.
All research outputs
#3,561,600
of 4,507,280 outputs
Outputs from BMC Neuroscience
#518
of 640 outputs
Outputs of similar age
#75,365
of 93,910 outputs
Outputs of similar age from BMC Neuroscience
#36
of 42 outputs
Altmetric has tracked 4,507,280 research outputs across all sources so far. This one is in the 3rd percentile – i.e., 3% of other outputs scored the same or lower than it.
So far Altmetric has tracked 640 research outputs from this source. They receive a mean Attention Score of 2.9. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 93,910 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 42 others from the same source and published within six weeks on either side of this one. This one is in the 2nd percentile – i.e., 2% of its contemporaries scored the same or lower than it.