Title |
HIV interactions with monocytes and dendritic cells: viral latency and reservoirs
|
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Published in |
Retrovirology, June 2009
|
DOI | 10.1186/1742-4690-6-51 |
Pubmed ID | |
Authors |
Christopher M Coleman, Li Wu |
Abstract |
HIV is a devastating human pathogen that causes serious immunological diseases in humans around the world. The virus is able to remain latent in an infected host for many years, allowing for the long-term survival of the virus and inevitably prolonging the infection process. The location and mechanisms of HIV latency are under investigation and remain important topics in the study of viral pathogenesis. Given that HIV is a blood-borne pathogen, a number of cell types have been proposed to be the sites of latency, including resting memory CD4+ T cells, peripheral blood monocytes, dendritic cells and macrophages in the lymph nodes, and haematopoietic stem cells in the bone marrow. This review updates the latest advances in the study of HIV interactions with monocytes and dendritic cells, and highlights the potential role of these cells as viral reservoirs and the effects of the HIV-host-cell interactions on viral pathogenesis. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 6 | 2% |
Portugal | 2 | <1% |
South Africa | 2 | <1% |
Brazil | 1 | <1% |
Australia | 1 | <1% |
Germany | 1 | <1% |
Canada | 1 | <1% |
United Kingdom | 1 | <1% |
Spain | 1 | <1% |
Other | 1 | <1% |
Unknown | 229 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 62 | 25% |
Researcher | 48 | 20% |
Student > Master | 32 | 13% |
Student > Bachelor | 28 | 11% |
Student > Postgraduate | 15 | 6% |
Other | 35 | 14% |
Unknown | 26 | 11% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 93 | 38% |
Medicine and Dentistry | 43 | 17% |
Immunology and Microbiology | 31 | 13% |
Biochemistry, Genetics and Molecular Biology | 25 | 10% |
Chemistry | 7 | 3% |
Other | 18 | 7% |
Unknown | 29 | 12% |